Serine and one-carbon metabolism in cancer

被引：643
|
作者：
Yang, Ming [1 ]
Vousden, Karen H. [1 ]
机构：
[1] Canc Res UK Beatson Inst, Switchback Rd, Glasgow G61 1BD, Lanark, Scotland
来源：
NATURE REVIEWS CANCER | 2016年 / 16卷 / 10期
基金：
欧洲研究理事会;
关键词：
NOVO THYMIDYLATE BIOSYNTHESIS; PYRUVATE-KINASE M2; PHOSPHOGLYCERATE DEHYDROGENASE; 3-PHOSPHOGLYCERATE DEHYDROGENASE; SYNTHESIS PATHWAY; HOMOCYSTEINE REMETHYLATION; GLYCINE DECARBOXYLASE; REDOX HOMEOSTASIS; OXIDATIVE STRESS; CELL SURVIVAL;
D O I：
10.1038/nrc.2016.81
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells, including protein, amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle, serine contributes to nucleotide synthesis, methylation reactions and the generation of NADPH for antioxidant defence. Many cancer cells are highly dependent on serine, a trait that provides several novel therapeutic opportunities, either through the inhibition of de novo serine synthesis or by limiting the availability or uptake of exogenous serine.
引用
收藏
页码：650 / 662
页数：13
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