Resveratrol regulates naive CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression

被引：12
|
作者：
Noh, Kyung Tae [1 ]
Cho, Joon [2 ]
Chun, Sung Hak [3 ,4 ]
Jang, Jong-Hwa [5 ]
Cha, Gil Sun [3 ,4 ]
Jung, In Duk [3 ,4 ]
Jang, Dong Deuk [1 ]
Park, Yeong-Min [3 ,4 ]
机构：
[1] Armed Forces Med Res Inst, Dept Infect Dis, Daejeon 305878, South Korea
[2] Konkuk Univ, Coll Med, Dept Neurosurg, Seoul 143701, South Korea
[3] Konkuk Univ, KU Open Innovat Ctr, Dept Immunol, Lab Dendrit Cell Differentiat & Regulat, Chungju 380701, South Korea
[4] Konkuk Univ, Sch Med, Chungju 380701, South Korea
[5] Hanseo Univ, Dept Dent Hyg, Seosan 356706, South Korea
来源：
BMB REPORTS | 2015年 / 48卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
Bone marrow-derived dendritic cells; CD8(+) T cell; Glycogen synthase kinase 3; Resveratrol; Tryptophanyl-tRNA synthetase; DENDRITIC CELLS; INDOLEAMINE 2,3-DIOXYGENASE; IN-VIVO; CANCER; IDO; INDOLEAMINE-2,3-DIOXYGENASE; MATURATION; TOLERANCE; APOPTOSIS; THERAPY;
D O I：
10.5483/BMBRep.2015.48.5.190
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We found that resveratrol enhances interferon (IFN)-gamma-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3 beta (GSK-3 beta) activity. In addition, we found that resveratrol regulates naive CD8(+) T-cell polarization by modulating GSK-3 beta activity in IFN-gamma-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8(+) T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN-gamma-induced TTS expression in a GSK-3 beta-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation.
引用
收藏
页码：283 / 288
页数：6
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