Resveratrol regulates naive CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression

被引：12

作者：

Noh, Kyung Tae ^{[1
]}

Cho, Joon ^{[2
]}

Chun, Sung Hak ^{[3
,4
]}

Jang, Jong-Hwa ^{[5
]}

Cha, Gil Sun ^{[3
,4
]}

Jung, In Duk ^{[3
,4
]}

Jang, Dong Deuk ^{[1
]}

Park, Yeong-Min ^{[3
,4
]}

机构：

[1] Armed Forces Med Res Inst, Dept Infect Dis, Daejeon 305878, South Korea

[2] Konkuk Univ, Coll Med, Dept Neurosurg, Seoul 143701, South Korea

[3] Konkuk Univ, KU Open Innovat Ctr, Dept Immunol, Lab Dendrit Cell Differentiat & Regulat, Chungju 380701, South Korea

[4] Konkuk Univ, Sch Med, Chungju 380701, South Korea

[5] Hanseo Univ, Dept Dent Hyg, Seosan 356706, South Korea

来源：

BMB REPORTS | 2015年 / 48卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Bone marrow-derived dendritic cells; CD8(+) T cell; Glycogen synthase kinase 3; Resveratrol; Tryptophanyl-tRNA synthetase; DENDRITIC CELLS; INDOLEAMINE 2,3-DIOXYGENASE; IN-VIVO; CANCER; IDO; INDOLEAMINE-2,3-DIOXYGENASE; MATURATION; TOLERANCE; APOPTOSIS; THERAPY;

D O I：

10.5483/BMBRep.2015.48.5.190

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We found that resveratrol enhances interferon (IFN)-gamma-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow-derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3 beta (GSK-3 beta) activity. In addition, we found that resveratrol regulates naive CD8(+) T-cell polarization by modulating GSK-3 beta activity in IFN-gamma-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8(+) T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN-gamma-induced TTS expression in a GSK-3 beta-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation.

引用

页码：283 / 288

页数：6

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