A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1nr phenotype

被引：24
|
作者：
Jung, YT [1 ]
Kozak, CA [1 ]
机构：
[1] NIAID, Mol Microbiol Lab, Bethesda, MD 20892 USA
来源：
JOURNAL OF VIROLOGY | 2000年 / 74卷 / 11期
关键词：
D O I：
10.1128/JVI.74.11.5385-5387.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns.
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页码：5385 / 5387
页数：3
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