A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1nr phenotype

被引：24

作者：

Jung, YT ^{[1
]}

Kozak, CA ^{[1
]}

机构：

[1] NIAID, Mol Microbiol Lab, Bethesda, MD 20892 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 11期

关键词：

D O I：

10.1128/JVI.74.11.5385-5387.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns.

引用

页码：5385 / 5387

页数：3

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