Semisynthetic tellurosubtilisin with glutathione peroxidase activity

被引：70

作者：

Mao, SZ ^{[1
]}

Dong, ZY ^{[1
]}

Liu, JQ ^{[1
]}

Li, XQ ^{[1
]}

Liu, XM ^{[1
]}

Luo, GM ^{[1
]}

Shen, JC ^{[1
]}

机构：

[1] Jilin Univ, Key Lab Supramol Struct & Mat, Minist Educ, Changchun 130012, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 33期

关键词：

D O I：

10.1021/ja052451v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of the hydroxyl group of serine-221 of subtilisin with phenylmethanesulfonylfluoride followed by nucleophilic substitution with sodium hydrogen telluride, a semisynthetic telluroprotein, tellurosubtilisin, was prepared. Tellurosubtilisin, which displays high substrate specificity for aromatic thiols, exhibits remarkable peroxidase activity and catalyzes the reduction of hydrogen peroxide by 3-carboxy-4-nitrobenzenethiol 20000 times more efficiently than diphenyl diselenide. Copyright © 2005 American Chemical Society.

引用

页码：11588 / 11589

页数：2

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