N-H carbazole synthesis from 2-chloroanilines via consecutive amination and C-H activation

被引：159

作者：

Bedford, Robin B. ^{[1
]}

Betham, Michael ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 25期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/jo061749g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-H carbazoles can be produced from 2-chloroanilines and aryl bromides via consecutive catalytic amination and C-H activation. In many instances, this can be done in a tandem manner in one pot. The methodologies developed can be used in the synthesis of a range of carbazoles, including the natural products Clausine P and glycozolidine and a precursor in the synthesis of Clausines H, K, O, and 7-methoxy-O-methylmukonal, and can be extended to the synthesis of indoles.

引用

页码：9403 / 9410

页数：8

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