Structures and antiviral activities of polysaccharides from Sargassum trichophyllum

被引:71
|
作者
Lee, Jung-Bum [1 ]
Takeshita, Azumi [1 ]
Hayashi, Kyoko [1 ]
Hayashi, Toshimitsu [1 ]
机构
[1] Toyama Univ, Grad Sch Med & Pharmaceut Sci Res, Lab Phamacognosy, Toyama 9300194, Japan
关键词
Sargassum trichophyllum; Laminaran; Alginate; Fucoidan; Antiviral activity; SULFATED POLYSACCHARIDES; GREEN-ALGAE; BROWN-ALGAE; ALGINATE; FUCOIDANS; HORNERI;
D O I
10.1016/j.carbpol.2011.05.059
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Isolation and characterization of polysaccharides from Sargassum trichophyllum. a type of brown algae, were performed. Three polysaccharides, ST-L, -A and -F were obtained and characterized as laminaran, alginate and fucoidan, respectively. ST-L was found to be a beta-glucan consisting of terminal- (14.5 mol%), 1,3- (69.4%), 1,6- (33.4%), and 1,3,6-linked (12.8%) residues. ST-A was found to be a mannuronic acid-rich alginate (M/G = 1.88). ST-F consisted of fucose (79.1 mol%) and galactose (19.9 mol%), and its sulfate content was estimated to be 25.5%. Methylation analysis revealed that ST-F was mainly composed of terminal, 1,4- and 1,3-linked fucose and terminal. 1,2- and 1,6-linked galactose residues. Among these polysaccharides, only ST-F showed antiviral activity against herpes simplex virus type 2. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:995 / 999
页数:5
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