Why do cells have multiple error-prone DNA polymerases?

被引：26

作者：

Friedberg, EC ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Pathol, Lab Mol Pathol, Dallas, TX 75390 USA

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2001年 / 38卷 / 2-3期

关键词：

error-prone DNA polymerises; UV radiation; E; coli; prokaryotic cells; eukaryotic cells;

D O I：

10.1002/em.1059

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Recent years have witnessed the emergence of a plethora of so-called novel DNA polymerases in both eukaryotic and prokaryotic cells. Many of these DNA polymerases are characterized by poor replicational fidelity and low processivity, and are devoid of 3 ' --> 5 ' exonuclease activity. This article describes the discovery of these error-prone polymerases and what is known about their biological function. Environ. Mol. Mutagen. (C) 2001 Wiley-Liss, Inc.

引用

页码：105 / 110

页数：6

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