Error-prone bypass of certain DNA lesions by the human DNA polymerase κ

被引：0
|
作者：
Ohashi, E
Ogi, T
Kusumoto, R
Iwai, S
Masutani, C
Hanaoka, F
Ohmori, H [1 ]
机构：
[1] Kyoto Univ, Inst Virus Res, Kyoto 6068507, Japan
[2] Osaka Univ, Inst Mol & Cellular Biol, Suita, Osaka 5650871, Japan
[3] Japan Sci & Technol Corp, CREST, Suita, Osaka 5650871, Japan
[4] Biomol Engn Res Inst, Osaka 5650874, Japan
来源：
GENES & DEVELOPMENT | 2000年 / 14卷 / 13期
关键词：
DINB1; pol kappa; abasic site; AAF; mutation; sequence context;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Escherichia coli protein DinB is a newly identified error-prone DNA polymerase. Recently, a human homolog of DinB was identified and named DINB1. We report that the DINB1 gene encodes a DNA polymerase (designated pol kappa), which incorporates mismatched bases on a nondamaged template with a high frequency. Moreover, pol kappa bypasses an abasic site and N-2-acetylaminofluorene (AAF)-adduct in an error-prone manner but does not bypass a cis-syn or (6-4) thymine-thymine dimer or a cisplatin-adduct. Therefore, our results implicate an important role for pol kappa in the mutagenic bypass of certain types of DNA lesions.
引用
收藏
页码：1589 / 1594
页数：6
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