Identification of a cDNA encoding 6-phosphogluconate dehydrogenase from a human heart cDNA library

被引：18
|
作者：
Tsui, SKW [1 ]
Chan, JYW [1 ]
Waye, MMY [1 ]
Fung, KP [1 ]
Lee, CY [1 ]
机构：
[1] CHINESE UNIV HONG KONG,DEPT BIOCHEM,SHATIN,NT,HONG KONG
来源：
BIOCHEMICAL GENETICS | 1996年 / 34卷 / 9-10期
关键词：
6-phosphogluconate dehydrogenase; carbon metabolism; pentose phosphate pathway; DNA sequence; Homo sapiens;
D O I：
10.1007/BF00554412
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A full-length cDNA clone for human 6-phosphogluconate dehydrogenase (PGD) was isolated from a human adult heart cDNA library. The clone encoded an open reading frame of 483 amino acids. When the amino acid sequences of human PGD and sheep PGD were aligned, 94.2% identity between these two proteins was found Its calculated molecular weight is 53,149 daltons. The predicted isoelectric point is 6.85. When the secondary structure of human PGD was examined by the PROSIS software, 36% alpha-helix and 9% beta-sheet were found.
引用
收藏
页码：367 / 373
页数：7
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