THREE NEW ISOINDOLIN-1-ONES FROM THE LEAVES OF YUNNAN LOCAL SUN CURED TOBACCO AND THEIR BIOACTIVITIES

被引：12
|
作者：
Zhang, Feng-Mei [1 ,2 ]
Xia, Jian-Jun [1 ,2 ]
Yang, Pei-Song [1 ,2 ]
Shen, Qin-Peng [1 ]
Liu, Chun-Bo [1 ]
He, Pei [1 ]
Wang, Jia-Qiang [1 ]
Liu, Zhi-Hua [2 ]
Ding, Zhong-Tao [1 ]
机构：
[1] Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
[2] China Tobacco Yunnan Ind Co Ltd, Ctr Res & Dev, Key Lab Tobacco Chem Yunnan Prov, Kunming 650231, Peoples R China
来源：
HETEROCYCLES | 2016年 / 92卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Isoindolin-1-one; Yunnan Local Sun Cured Tobacco; Anti-Tobacco Mosaic Virus Activity; Cytotoxicity Activity; MOSAIC-VIRUS ACTIVITIES; NICOTIANA-TABACUM; SESQUITERPENE GLUCOSIDES; ANTITOBACCO; DERIVATIVES; FLAVONOIDS; ROOTS; STEMS; CYTOTOXICITY;
D O I：
10.3987/COM-16-13521
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three new (1-3) and one known (4) isoindolin-1-ones were isolated from the leaves of Yunnan local sun cured tobacco. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-3 were tested for their anti-tobacco mosaic virus (anti-TMV) activities and compounds 1-4 were tested for their cytotoxicity activities. The results showed that compounds 1-3 showed high anti-TMV activity with inhibition rates of 43.8, 45.6 and 52.7%. These rates are higher than that of positive control. Compounds 1-4 also showed moderate-to-weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 2.8-8.2 mu M.
引用
收藏
页码：1713 / 1720
页数：8
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