Generation of an induced pluripotent stem cell line HUSTTJi001-A from a Moyamoya disease patient with RNF213 gene mutation

被引：1
|
作者：
Mao, Zhijuan [1 ]
Li, Yunjie [1 ]
Huang, Liangjiang [2 ]
Chen, Yunqiang [2 ]
Luo, Hongmei [2 ]
Zhang, Suming [1 ]
Chen, Hong [2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurol, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rehabil Med, Wuhan 430030, Peoples R China
[3] Key Lab Neural Injury & Funct Reconstruct Hubei P, Wuhan, Hubei, Peoples R China
来源：
STEM CELL RESEARCH | 2021年 / 57卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.scr.2021.102575
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Moyamoya disease (MMD) is an idiopathic and chronic steno-occlusive cerebrovascular disease. Genetic studies identified RNF213 as a principal susceptibility gene of MMD. In this study, peripheral blood mononuclear cells (PBMCs) were obtained from an MMD patient with RNF213 p. R4810K mutations, and the PBMCs were then reprogrammed to induced pluripotent stem cells (iPSCs) by the transfection of non-integrated episomal vectors. The iPSC line shows pluripotency markers and has the potential for in vitro differentiation into three germ layers, and will be valuable for elucidating the underlying cellular mechanisms of MMD, selecting therapeutic targets, and developing drugs.
引用
收藏
页数：3
相关论文
共 50 条
  • [41] Significance of Carotid Canal Plasticity and the RNF213 p.R4810K Mutation in Distinguishing Moyamoya Disease From Middle Cerebral Artery Disease
    Oichi, Yuki
    Mineharu, Yohei
    Morimoto, Takaaki
    Agawa, Yuji
    Funaki, Takeshi
    Hitomi, Toshiaki
    Kobayashi, Hatasu
    Todo, Kenichi
    Tani, Shoichi
    Imamura, Hirotoshi
    Koizumi, Akio
    Sakai, Nobuyuki
    Miyamoyo, Susumu
    NEUROSURGERY, 2020, 67 : 110 - 111
  • [42] Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection
    Mishra, Ketan
    Junday, Keerat
    Wong, Claire M. Y.
    Chan, Andrea Y.
    Hesselson, Stephanie
    Muller, David W.
    Iismaa, Siiri E.
    Mehta, Ashish
    Graham, Robert M.
    STEM CELL RESEARCH, 2019, 41
  • [43] Generation of an induced pluripotent stem cell line (UBCi001-A) from a presymptomatic individual carrying the R418X progranulin gene mutation
    Frew, J.
    Wu, X.
    Hsiung, G. Y.
    Feldman, H. H.
    Mackenzie, I. R.
    Nygaard, H. B.
    STEM CELL RESEARCH, 2019, 41
  • [44] Generation of human induced pluripotent stem cell (iPSC) line from an unaffected female carrier of mutation in SACSIN gene
    Machuca, Candela
    Vilches, Angel
    Clemente, Eleonora
    Ignacio Pascual-Pascual, Samuel
    Bolinches-Amoros, Arantxa
    Artero Castro, Ana
    Espinos, Carmen
    Leon, Marian
    Jendelova, Pavla
    Erceg, Slaven
    STEM CELL RESEARCH, 2018, 33 : 166 - 170
  • [45] Generation of human induced pluripotent stem cell line (XWHNi004-A) from a male with APOE gene mutation
    Wang, Pin
    Sun, Wenxian
    Gong, Jin
    Han, Xiaodong
    Xu, Chang
    Chen, Yufei
    Yang, Yuting
    Luan, Heya
    Li, Shaoqi
    Li, Ruina
    Wen, Boye
    Lv, Sirong
    Chen, Runqi
    Guo, Jinxuan
    Wei, Cuibai
    STEM CELL RESEARCH, 2024, 77
  • [46] Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease
    Li, Bo
    Yang, Yitong
    Wang, Yingxin
    Shan, Didi
    Li, Jianing
    Wang, Hongxu
    Sun, Xiaohan
    Tang, Yao
    Jiao, Yichang
    Ji, Xinbo
    Zhan, Zexin
    Kong, Bo
    Gao, Bo
    Wang, Yu
    Sun, Ping
    Liu, Fuchen
    STEM CELL RESEARCH, 2025, 82
  • [47] Establishment of an induced pluripotent stem cell line (SHFDi001-A) from a patient with ankylosing spondylitis
    Hu, Jintao
    Lu, Chuanjia
    Zhu, Wenjing
    Jiang, Qun
    Du, Weibin
    Wu, Nan
    STEM CELL RESEARCH, 2020, 46
  • [48] Establishment of an induced pluripotent stem cell line (FDEENTi001-A) from a patient with pathological myopia
    Bai, Xinyue
    Yang, Xianjie
    Cheng, Yun
    Chen, Ling
    STEM CELL RESEARCH, 2019, 34
  • [49] Generation of induced pluripotent stem cell line (NCKDi001-A) from a 19-year-old patient with a novel COL4A5 gene mutation in Alport syndrome
    Wang, Gang
    Wu, Hangdi
    Gao, Erzhi
    Zhang, Li
    Chen, Lang
    Zhu, Yuqing
    Zhang, Jin
    Liu, Zhihong
    STEM CELL RESEARCH, 2020, 49
  • [50] Generation of the induced pluripotent stem cell line (ZSPHARi001-A) from a patient with recessive dystrophic epidermolysis bullosa carrying compound heterozygous mutation in the COL7A1 gene
    Zhang, Yeye
    Fan, Jun
    Lu, Guangzhao
    Xu, Genying
    Lv, Qianzhou
    STEM CELL RESEARCH, 2022, 60
12345