Generation of an induced pluripotent stem cell line HUSTTJi001-A from a Moyamoya disease patient with RNF213 gene mutation

被引：1
|
作者：
Mao, Zhijuan [1 ]
Li, Yunjie [1 ]
Huang, Liangjiang [2 ]
Chen, Yunqiang [2 ]
Luo, Hongmei [2 ]
Zhang, Suming [1 ]
Chen, Hong [2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurol, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rehabil Med, Wuhan 430030, Peoples R China
[3] Key Lab Neural Injury & Funct Reconstruct Hubei P, Wuhan, Hubei, Peoples R China
来源：
STEM CELL RESEARCH | 2021年 / 57卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.scr.2021.102575
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Moyamoya disease (MMD) is an idiopathic and chronic steno-occlusive cerebrovascular disease. Genetic studies identified RNF213 as a principal susceptibility gene of MMD. In this study, peripheral blood mononuclear cells (PBMCs) were obtained from an MMD patient with RNF213 p. R4810K mutations, and the PBMCs were then reprogrammed to induced pluripotent stem cells (iPSCs) by the transfection of non-integrated episomal vectors. The iPSC line shows pluripotency markers and has the potential for in vitro differentiation into three germ layers, and will be valuable for elucidating the underlying cellular mechanisms of MMD, selecting therapeutic targets, and developing drugs.
引用
收藏
页数：3
相关论文
共 50 条
  • [21] Generation of a human induced pluripotent stem cell line (UNAMi001-A) from a Mexican patient with sporadic Parkinson's disease
    Flores-Ponce, Xochitl
    Lopez-Ornelas, Adolfo
    Escobedo-Avila, Itzel
    Rodriguez-Violante, Mayela
    Davila-Ortiz De Montellano, David
    Cervantes-Arriaga, Amin
    Monroy-Jaramillo, Nancy
    Velasco, Ivan
    STEM CELL RESEARCH, 2022, 65
  • [22] Generation of induced pluripotent stem cell line from a patient with long COVID
    Wu, David
    Manhas, Amit
    Noishiki, Chikage
    Tripathi, Dipti
    Liu, Lu
    Turbes, Naima
    Thomas, Dilip
    Sallam, Karim
    Lee, Jason T.
    Sayed, Nazish
    STEM CELL RESEARCH, 2025, 83
  • [23] Generation of integration-free induced pluripotent stem cell line (NJMUi001-A) from a phenylketonuria patient
    Xu, Tianhui
    Liang, Dong
    Zhang, Jingjing
    Ji, Xiuqing
    Hu, Huanran
    Sun, Yun
    Jiang, Tao
    Wang, Xia
    Hu, Ping
    Xu, Zhengfeng
    STEM CELL RESEARCH, 2017, 25 : 179 - 182
  • [24] Generation of induced pluripotent stem cell line (XWHNi003-A) from a female with APOE gene mutation
    Gong, Jin
    Li, Shaoqi
    Sun, Wenxian
    Wang, Pin
    Han, Xiaodong
    Xu, Chang
    Chen, Yufei
    Yang, Yuting
    Luan, Heya
    Li, Ruina
    Wen, Boye
    Lv, Sirong
    Chen, Runqi
    Guo, Jinxuan
    Wei, Cuibai
    STEM CELL RESEARCH, 2024, 79
  • [25] Generation of induced pluripotent stem cell line (XWHNi002-A) from a female with APP gene mutation
    Sun, Wenxian
    Wang, Pin
    Gong, Jin
    Chen, Yufei
    Yang, Yuting
    Luan, Heya
    Li, Shaoqi
    Li, Ruina
    Wei, Cuibai
    STEM CELL RESEARCH, 2023, 71
  • [26] A generation of human-induced pluripotent stem cell line (MUi032-A) from a Choroideremia disease patient carrying a hemizygous mutation on the CHM gene
    Pongpaksupasin, Phitchapa
    Wongkummool, Wasinee
    Tong-Ngam, Pirut
    Jearawiriyapaisarn, Natee
    Paiboonsukwong, Kittiphong
    Sangkitporn, Siripakorn
    Trinavarat, Adisak
    Atchaneeyasakul, La-Ongsri
    Tubsuwan, Alisa
    STEM CELL RESEARCH, 2022, 65
  • [27] Generation of an induced pluripotent stem cell line (SMBCi022-A) from a patient with Fabry disease
    Li, Zihan
    Luan, Jing
    Yang, Yali
    Li, Guowei
    Hu, Zhouhui
    Yu, Che
    Cui, Yazhou
    Han, Jinxiang
    STEM CELL RESEARCH, 2025, 83
  • [28] Posterior cerebral artery involvement in unilateral moyamoya disease is exclusively ipsilateral and influenced by RNF213 mutation gene dose: The SUPRA Japan study PCA involvement in unilateral moyamoya
    Mineharu, Yohei
    Takagi, Yasushi
    Koizumi, Akio
    Morimoto, Takaaki
    Funaki, Takeshi
    Hishikawa, Tomohito
    Araki, Yoshio
    Hasegawa, Hitoshi
    Takahashi, Jun C.
    Kuroda, Satoshi
    Houkin, Kiyohiro
    Miyamoto, Susumu
    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2024, 33 (02):
  • [29] Generation of CSi001-A, a transgene-free, induced pluripotent stem cell line derived from a Parkinson Disease (PD) patient
    Zhao, Zongbo
    Ji, Sunping
    Shi, Zhige
    Liu, Hui
    STEM CELL RESEARCH, 2018, 33 : 1 - 5
  • [30] Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient
    Ma, Jun
    Guo, Ruiyun
    Song, Yongzhou
    Zhang, Jing
    Feng, Baofeng
    Amponsah, Asiamah Ernest
    Kong, Desheng
    He, Jingjing
    Zhang, Wei
    Liu, Aijing
    Wei, Lin
    Shen, Sanbing
    O'Brien, Timothy
    Cui, Huixian
    STEM CELL RESEARCH, 2019, 36
12345