DNA interactions of ruthenium(II) complexes with a polypyridyl ligand: 2-(2, 5-dimethoxyphenyl)-1H-imidazo[4,5-f]1,10-phenanthroline

被引：11
|
作者：
Vidhisha, S. [1 ]
Reddy, Kotha Laxma [1 ]
Kumar, K. Ashwini [1 ]
Kumar, Yata Praveen [1 ]
Satyanarayana, S. [1 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
TRANSITION METAL CHEMISTRY | 2010年 / 35卷 / 08期
关键词：
DOUBLE-HELICAL DNA; COBALT(III) COMPLEXES; DEOXYRIBONUCLEIC-ACID; BINDING PROPERTIES; PHOTOCLEAVAGE; CLEAVAGE; TRIS(PHENANTHROLINE)RUTHENIUM(II); FLUORESCENCE; PHOTOPHYSICS;
D O I：
10.1007/s11243-010-9427-1
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
This article describes the synthesis of a polypyridyl ligand, namely 2-(2, 5-dimethoxyphenyl)-1H-imidazo[4,5-f]1,10-phenanthroline (DMPIP) and its Ru(II) complexes, namely [Ru(bipy)(2)DMPIP](2+) (1), [Ru(dmb)(2)DMPIP](2+) (2) and [Ru(phen)(2)DMPIP](2+) (3) ((bipy = 2,2'-bipyridine, dmb = 4,4'-dimethyl-2,2'-bipyridine, phen = 1,10-phenanthroline). The complexes were characterized by elemental analysis, plus IR, H-1-NMR and C-13 [H-1]-NMR spectra. The interactions of the complexes with calf thymus DNA were investigated. The results indicate that the three complexes can intercalate into DNA. Under irradiation at 365 nm, all three complexes promote the photocleavage of plasmid pBR 322 DNA. Inhibitor studies suggest that singlet oxygen plays a significant role in the cleavage mechanism for the complexes.
引用
收藏
页码：1027 / 1034
页数：8
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