DNA interactions of ruthenium(II) complexes with a polypyridyl ligand: 2-(2, 5-dimethoxyphenyl)-1H-imidazo[4,5-f]1,10-phenanthroline

被引：11
|
作者：
Vidhisha, S. [1 ]
Reddy, Kotha Laxma [1 ]
Kumar, K. Ashwini [1 ]
Kumar, Yata Praveen [1 ]
Satyanarayana, S. [1 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
TRANSITION METAL CHEMISTRY | 2010年 / 35卷 / 08期
关键词：
DOUBLE-HELICAL DNA; COBALT(III) COMPLEXES; DEOXYRIBONUCLEIC-ACID; BINDING PROPERTIES; PHOTOCLEAVAGE; CLEAVAGE; TRIS(PHENANTHROLINE)RUTHENIUM(II); FLUORESCENCE; PHOTOPHYSICS;
D O I：
10.1007/s11243-010-9427-1
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
This article describes the synthesis of a polypyridyl ligand, namely 2-(2, 5-dimethoxyphenyl)-1H-imidazo[4,5-f]1,10-phenanthroline (DMPIP) and its Ru(II) complexes, namely [Ru(bipy)(2)DMPIP](2+) (1), [Ru(dmb)(2)DMPIP](2+) (2) and [Ru(phen)(2)DMPIP](2+) (3) ((bipy = 2,2'-bipyridine, dmb = 4,4'-dimethyl-2,2'-bipyridine, phen = 1,10-phenanthroline). The complexes were characterized by elemental analysis, plus IR, H-1-NMR and C-13 [H-1]-NMR spectra. The interactions of the complexes with calf thymus DNA were investigated. The results indicate that the three complexes can intercalate into DNA. Under irradiation at 365 nm, all three complexes promote the photocleavage of plasmid pBR 322 DNA. Inhibitor studies suggest that singlet oxygen plays a significant role in the cleavage mechanism for the complexes.
引用
收藏
页码：1027 / 1034
页数：8
相关论文
共 50 条
  • [21] 1H-imidazo[4,5-f][1,10]phenanthroline carbohydrate conjugates: Synthesis, DNA interactions and cytotoxic activity
    Gratal, Patricia
    Arias-Perez, Maria-Selma
    Gude, Lourdes
    [J]. BIOORGANIC CHEMISTRY, 2022, 125
  • [22] Hydrothermal Processing, Structural Characterization and Theoretical Calculations of Two Copper (I) Complexes with 1,10-phenanthroline Derivatives Ligand: 2-(4-Methoxyphenyl)-1H-imidazo [4, 5-f] [1,10] phenanthroline
    Huang, Yan-Ju
    Yan, Yong-Sheng
    Pan, Ya-Ru
    Zhang, Hong-Yan
    [J]. JOURNAL OF CLUSTER SCIENCE, 2015, 26 (03) : 925 - 936
  • [23] Hydrothermal Processing, Structural Characterization and Theoretical Calculations of Two Copper (I) Complexes with 1,10-phenanthroline Derivatives Ligand: 2-(4-Methoxyphenyl)-1H-imidazo [4, 5-f] [1,10] phenanthroline
    Yan-Ju Huang
    Yong-Sheng Yan
    Ya-Ru Pan
    Hong-Yan Zhang
    [J]. Journal of Cluster Science, 2015, 26 : 925 - 936
  • [24] Bis(2,2'-bipyridine)ruthenium(II) complexes with imidazo[4,5-f][1,10]phenanthroline or 2-phenylimidazo[4,5-f][1,10]phenanthroline (pg 1395, 1997)
    Wu, JZ
    Ye, BH
    Wang, L
    Ji, LN
    Zhou, JY
    Li, RH
    Zhou, ZY
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1997, (11): : 1989 - 1989
  • [25] DNA binding, photocleavage, antimicrobial and cytotoxic properties of Ru(II) polypyridyl complexes containing BOPIP ligand, (BOPIP = {2-(4-(benzyloxy) phenyl)-1H-imidazo [4,5-f] [1,2]phenanthroline})
    Gopu, Srinivas
    Kumar, Vuradi Ravi
    Reddy, Kotha Laxma
    Reddy, Putta Venkat
    Sirasani, Satyanarayana
    [J]. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2019, 38 (05): : 349 - 373
  • [26] Studies on the DNA binding and anticancer activity of Ru(II) polypyridyl complexes by using a (2-(4-(diethoxymethyl)-1H-imidazo[4,5-f][1,10] phenanthroline)) intercalative ligand (vol 42, pg 846, 2018)
    Vuradi, Ravi Kumar
    Dandu, Kamakshi
    Yata, Praveen Kumar
    Rani, Vinoda M.
    Mallepally, Rajender Reddy
    Chintakuntla, Nagamani
    Ravi, Ch.
    Thakur, Suman S.
    Rao, Ch. Mohan
    Satyanarayana, S.
    [J]. NEW JOURNAL OF CHEMISTRY, 2019, 43 (32) : 12874 - 12874
  • [27] Synthesis and DNA interaction studies of a binuclear ruthenium(II) complex with 2,9-bis(2-imidazo[4,5-f][1,10]phenanthroline)-1,10-phenanthroline as bridging and intercalating ligand
    Wu, JZ
    Yuan, L
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (01) : 41 - 45
  • [28] Synthesis, DNA-binding, and antitumor activity of polypyridyl-ruthenium(II) complexes [Ru(L)2(DClPIP)] (L = bpy, phen; DClPIP=2-(2,4-dichlorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline)
    Guan, Shouhai
    Pan, Tao
    Zhang, Yanyang
    Zeng, Zhaolin
    Mu, Luwen
    Zhu, Duo
    Chang, Boyang
    Zheng, Kangdi
    Qian, Jiesheng
    Xie, Qiang
    Mei, Wenjie
    Tang, Wenjie
    Bai, Mingjun
    [J]. JOURNAL OF COORDINATION CHEMISTRY, 2019, 72 (12) : 2050 - 2064
  • [29] Biological evaluation of rare earth complexes bearing 1H-imidazo[4,5-f]-1,10-phenanthroline moiety as promising anticancer chemotherapeutics
    Liu, Yue
    Zhou, Xue-Quan
    Lu, Jing
    Li, Si-Tong
    Nie, Yan
    Tian, Jin-Lei
    Liu, Xin
    Yan, Shi-Ping
    [J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2018, 32 (12)
  • [30] 2-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenol monohydrate
    Zhang, Wen-Zhi
    Li, Li
    Xiao, Ying-Hui
    [J]. ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O1331 - U2513
12345