Synthesis, characterization and DNA-binding studies of chiral ruthenium(II) complexes with 2-(5-nitrofuran-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline

被引：20
|
作者：
Sun, Bin [1 ]
Wang, Yu-Chuan [1 ]
Qian, Chen [1 ]
Chu, Jun [1 ]
Liang, Si-Min [1 ]
Chao, Hui [1 ]
Ji, Liang-Nian [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2010年 / 963卷 / 2-3期
关键词：
Ru(II) complex; Polypyridyl ligand; Chiral; DNA binding; MOLECULAR LIGHT SWITCH; POLYPYRIDYL COMPLEXES; DEOXYRIBONUCLEIC-ACID; METAL-COMPLEXES; PHOTOCLEAVAGE; LIGANDS; TRIS(PHENANTHROLINE)RUTHENIUM(II); PHEN=1,10-PHENANTHROLINE; ANTICANCER; TRANSITION;
D O I：
10.1016/j.molstruc.2009.10.028
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Two new chiral ruthenium(II) complexes Delta-[Ru(bpy)(2)(nfip)](2+) and Lambda-[Ru(bpy)(2)(nfip)](2+) (in which bpy=2,2'-bipyridine, nfip=2-(5-nitrofuran-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline) have been synthesized and characterized by elemental analysis, ES-MS, H-1 NMR and CD spectra. The binding properties of two chiral complexes with calf thymus DNA have been investigated by different spectrophotometric methods and viscosity measurements. A subtle but detectable difference was observed in the interaction of both enantiomer with CT-DNA, Delta enantionner binds with DNA more strongly than Lambda enantiomer. Viscosity experiments provided evidence that both Delta-[Ru(bpy)(2)(nfip)](2+) and Lambda-[Ru(bpy)(2)(nfip)](2+) bound to DNA by intercalation. (c) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：153 / 159
页数：7
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