2-amino-X-nitrobenzimidazoles as precursors of food-borne carcinogens: A new approach to IQ synthesis

被引：9

作者：

Bella, Maros ^{[1
]}

Milata, Viktor ^{[1
]}

Larina, Lyudmila I. ^{[2
]}

机构：

[1] Slovak Univ Technol Bratislava, Dept Organ Chem, Inst Organ Chem Catalysis & Petrochem, Fac Chem & Food Technol, Bratislava 81237, Slovakia

[2] Russian Acad Sci, Siberian Branch, AE Favorsky Irkutsk Inst Chem, Irkutsk 664033, Russia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 02期

关键词：

C-13;

D O I：

10.1002/jhet.786

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclization of (non)-methylated nitro-o-phenylenediamines with cyanogen bromide provided nitro-substituted 2-aminobenzimidazoles in good up to excellent yields. Catalytic hydrogenation of 2-amino-1-methyl-5-nitrobenzimidazole yielded 2,5-diamino-1-methylbenzimidazole, which on treatment with 1,1,3,3-tetramethoxypropane in methanol and subsequently after removal of methanol in polyphosphoric acid afforded food-borne carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in 20% yield. J. Heterocyclic Chem.,(2011).

引用

页码：293 / 296

页数：4

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