A new approach to the synthesis of 3-amino- and 3-benzoylamino-5-aminoalkyl-1,2,4-triazoles

被引：0
|
作者：
M. A. Prezent
E. D. Daeva
S. V. Baranin
V. A. Dorokhov
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
来源：
Russian Chemical Bulletin | 2015年 / 64卷
关键词：
synthesis; catalyst; benzoylcyanamide; amino acid hydrazides; nickel(II) acetylacetonate; hydrochlorides of 3-amino-1,2,4-triazole derivatives;
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摘要：
Nickel(II) acetylacetonate for the first time was shown to efficiently catalyze the addition of Boc-protected amino acid hydrazides to the nitrile group of benzoylcyanamide with the formation of the corresponding 3-benzoylamino-substituted 1,2,4-triazoles with the Boc-aminoalkyl group at position 5. A further modification of the latter led, depending on the conditions, to mono- or dihydrochlorides of 1,2,4-triazole-derived amines.
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页码：1089 / 1092
页数：3
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