Arabidopsis calcium-binding mitochondrial carrier proteins as potential facilitators of mitochondrial ATP-import and plastid SAM-import

被引：44

作者：

Stael, Simon ^{[1
]}

Rocha, Agostinho G. ^{[2
]}

Robinson, Alan J. ^{[3
]}

Kmiecik, Przemyslaw ^{[1
]}

Vothknecht, Ute C. ^{[2
,4
]}

Teige, Markus ^{[1
]}

机构：

[1] Univ Vienna, MFPL, Dept Biochem & Cell Biol, A-1030 Vienna, Austria

[2] Ludwig Maximilians Univ Munchen, Dept Biol 1, D-82152 Planegg Martinsried, Germany

[3] MRC, Mitochondrial Biol Unit, Cambridge CB2 0XY, England

[4] Ludwig Maximilians Univ Munchen, Dept Biol, Ctr Integrated Prot Sci Munich, D-81377 Munich, Germany

来源：

FEBS LETTERS | 2011年 / 585卷 / 24期

基金：

英国医学研究理事会;

关键词：

Chloroplast; Mitochondria; Mitochondrial carrier protein; Calcium-binding; ATP-phosphate carrier; SAM transporter; SUSPENSION-CULTURED CELLS; SACCHAROMYCES-CEREVISIAE; FUNCTIONAL-CHARACTERIZATION; BACTERIAL EXPRESSION; ADP/ATP CARRIER; CYTOSOLIC CA2+; TISSUE DISTRIBUTION; GENE-EXPRESSION; THALIANA; CHLOROPLAST;

D O I：

10.1016/j.febslet.2011.10.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chloroplasts and mitochondria are central to crucial cellular processes in plants and contribute to a whole range of metabolic pathways. The use of calcium ions as a secondary messenger in and around organelles is increasingly appreciated as an important mediator of plant cell signaling, enabling plants to develop or to acclimatize to changing environmental conditions. Here, we have studied the four calcium-dependent mitochondrial carriers that are encoded in the Arabidopsis genome. An unknown substrate carrier, which was previously found to localize to chloroplasts, is proposed to present a calcium-dependent S-adenosyl methionine carrier. For three predicted ATP/phosphate carriers, we present experimental evidence that they can function as mitochondrial ATP-importers. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3935 / 3940

页数：6

共 43 条

[41] INVOLVEMENT OF THE ADP/ATP CARRIER IN CALCIUM-INDUCED PERTURBATIONS OF THE MITOCHONDRIAL INNER MEMBRANE-PERMEABILITY - IMPORTANCE OF THE ORIENTATION OF THE NUCLEOTIDE BINDING-SITE
LEQUOC, K
LEQUOC, D
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 265 (02) : 249 - 257
[42] Assignment of the SLC25A12 gene coding for the human calcium-binding mitochondrial solute carrier protein aralar to human chromosome 2q24
Crackower, MA
Sinasac, DS
Lee, JR
Herbrick, JA
Tsui, LC
Scherer, SW
CYTOGENETICS AND CELL GENETICS, 1999, 87 (3-4): : 197 - 198
[43] Assignment of the calcium-binding mitochondrial carrier Aralar1 gene (SLC25A12) to human chromosome band 2q31 by in situ hybridiration
Sanz, R
del Arco, A
Ayuso, C
Ramos, C
Satrústegui, J
CYTOGENETICS AND CELL GENETICS, 2000, 89 (3-4): : 143 - 144

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