Imides: forgotten players in the Ugi reaction. One-pot multicomponent synthesis of quinazolinones

被引：35

作者：

Mossetti, Riccardo ^{[1
]}

Pirali, Tracey ^{[1
]}

Saggiorato, Desiree ^{[1
]}

Tron, Gian Cesare ^{[1
]}

机构：

[1] Univ Piemonte Orientale, Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 24期

关键词：

AZA-WITTIG REACTION; 4-COMPONENT REACTION; NATURAL-PRODUCTS; HETEROCYCLES; DERIVATIVES; ANTAGONISTS; ISONITRILE; CHEMISTRY; AMINES; ROUTE;

D O I：

10.1039/c1cc12067k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Up to now, the synthesis of quinazolinones has required lengthy synthetic procedures. Here, we describe an innovative one-pot multicomponent reaction leading to highly substituted quinazolinones. We believe that this novel transformation may open the door for the generation of new and pharmacologically active quinazolinones, but, most important of all, the resurrection of the imide-Ugi scaffold paves the way for the synthesis of novel molecular architectures

引用

页码：6966 / 6968

页数：3

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