One-pot enzymatic desymmetrization and Ugi MCR

被引：15
|
作者：
Fryszkowska, A
Frelek, J
Ostaszewski, R
机构：
[1] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland
[2] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland
来源：
TETRAHEDRON | 2005年 / 61卷 / 25期
关键词：
enzyme; desymmetrization; peptidomimetic;
D O I：
10.1016/j.tet.2005.04.032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new approach to the synthesis of chiral peptidomimetics is reported. It combines an enzymatic desymmetrization of 3-phenylglutaric anhydrides with a subsequent Ugi multi-component reaction in a one-pot, two-step procedure. NMR and CD spectroscopy was used to assign the configurations of obtained products. Our synthetic method is very efficient and it can easily be extended to other types of multi-component reactions and can be used for the preparation of chiral peptidomimetic libraries. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6064 / 6072
页数：9
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