Cytotoxic diterpenoids from Euphorbia helioscopia

被引：61
|
作者：
Lu, Zhi-Qiang [1 ]
Guan, Shu-Hong [1 ]
Li, Xing-Nuo [1 ]
Chen, Guang-Tong [1 ]
Zhang, Jin-Qiang [1 ]
Huang, Hui-Lian [1 ]
Liu, Xuan [1 ]
Guo, De-An [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 05期
关键词：
D O I：
10.1021/np0706163
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new jatrophane-type diterpenoids (1-4), together with 16 known related compounds, were isolated from the Chinese medicinal plant Euphorbia helioscopia. The structures of 1-4 were determined on the basis of spectroscopic and chemical methods. Cytotoxicity of the isolated compounds against HeLa and MDA-MB-231 cells was evaluated, with only helioscopinolide A (5) and euphornin (3a) being active.
引用
收藏
页码：873 / 876
页数：4
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