Cytotoxic diterpenoids from Euphorbia helioscopia

被引：61

作者：

Lu, Zhi-Qiang ^{[1
]}

Guan, Shu-Hong ^{[1
]}

Li, Xing-Nuo ^{[1
]}

Chen, Guang-Tong ^{[1
]}

Zhang, Jin-Qiang ^{[1
]}

Huang, Hui-Lian ^{[1
]}

Liu, Xuan ^{[1
]}

Guo, De-An ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 05期

关键词：

D O I：

10.1021/np0706163

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new jatrophane-type diterpenoids (1-4), together with 16 known related compounds, were isolated from the Chinese medicinal plant Euphorbia helioscopia. The structures of 1-4 were determined on the basis of spectroscopic and chemical methods. Cytotoxicity of the isolated compounds against HeLa and MDA-MB-231 cells was evaluated, with only helioscopinolide A (5) and euphornin (3a) being active.

引用

页码：873 / 876

页数：4

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