Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia

被引：0
|
作者：
Hong-Wen Tao
Xiao-Jiang Hao
Pei-Pei Liu
Wei-Ming Zhu
机构：
[1] Ministry of Education,Key Laboratory of Marine Drugs
[2] Ocean University of China,School of Medicine and Pharmacy
[3] Chinese Academy of Sciences,The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany
来源：
Archives of Pharmacal Research | 2008年 / 31卷
关键词：
Diterpenoid; Euphornin L; X-ray; L; Cytotoxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new cytotoxic macrocyclic diterpenoid, euphornin L (1), together with seven known analogues were isolated from the plant Euphorbia helioscopia L. The structure of 1 was elucidated by spectral data and X-ray crystallographic analysis. Euphornin L (1) and euphoscopin F (2) exhibited significant cytotoxicity against HL-60 cell lines with IC50 values of 2.7 and 9.0 μM, respectively. The 13C-NMR data of euphoscopin F (2), epieuphoscopin B (3), euphoscopin B (5), and euphoscopin C (6) were also reported for the first time.
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页码：1547 / 1551
页数：4
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