Truncation of the C-terminus domain of topoisomerase IIα enhances enzymatic activity and reduces drug sensitivity

被引:0
|
作者
Chikamori, Kenichi
Andersen, Anni H.
Bukowski, Ronald M.
Ganapathi, Ram
Ganapathi, Mahrukh K.
机构
[1] Cleveland Clin Fdn, Cleveland, OH 44195 USA
[2] Aarhus Univ, DK-8000 Aarhus C, Denmark
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1938
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Expression of CD26 and its intrinsic dipeptidyl peptidase IV (DPPIV) enzyme activity enhances sensitivity to apoptosis mediated by topoisomerase II inhibitors.
    Sato, K
    Aytac, U
    Yamochi, T
    Yamochi, T
    Morimoto, C
    Dang, NH
    BLOOD, 2002, 100 (11) : 543A - 544A
  • [42] Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIβ:: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability
    West, KL
    Turnbull, RM
    Willmore, E
    Lakey, JH
    Austin, CA
    NUCLEIC ACIDS RESEARCH, 2002, 30 (24) : 5416 - 5424
  • [43] NUCLEAR TOPOISOMERASE-II ACTIVITY CHANGES DURING HL-60 LEUKEMIC-CELL DIFFERENTIATION - ALTERATIONS IN DRUG SENSITIVITY AND PH DEPENDENCY
    GIESELER, F
    BOEGE, F
    BIERSACK, H
    SPOHN, B
    CLARK, M
    WILMS, K
    LEUKEMIA & LYMPHOMA, 1991, 5 (04) : 273 - 279
  • [44] ATPase domain of eukaryotic DNA topoisomerase II Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization
    Hu, T
    Sage, H
    Hsieh, TS
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (08) : 5944 - 5951
  • [45] SOD-Like Activity of Copper(II) Containing Metallopeptides Branched By 2,3-Diaminopropionic Acid: What the N-Termini Elevate, the C-Terminus Ruins
    Szyrwiel, Lukasz
    Shimura, Mari
    Setner, Bartosz
    Szewczuk, Zbigniew
    Malec, Katarzyna
    Malinka, Wieslaw
    Brasun, Justyna
    Pap, Jozsef Sandor
    INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2019, 25 (02) : 711 - 717
  • [46] SOD-Like Activity of Copper(II) Containing Metallopeptides Branched By 2,3-Diaminopropionic Acid: What the N-Termini Elevate, the C-Terminus Ruins
    Łukasz Szyrwiel
    Mari Shimura
    Bartosz Setner
    Zbigniew Szewczuk
    Katarzyna Malec
    Wieslaw Malinka
    Justyna Brasun
    József Sándor Pap
    International Journal of Peptide Research and Therapeutics, 2019, 25 : 711 - 717
  • [47] Limited and defined truncation at the C terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2): Comparison of native and recombinant NAP-2 variants
    Ehlert, Jan E.
    Petersen, Frank
    Kubbutat, Michael H. G.
    Gerdes, Johannes
    Flad, Hans-Dieter
    Brandt, Ernst
    Journal of Biological Chemistry, 1995, 270 (11): : 6338 - 6344
  • [48] Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity
    Shiiba, Masashi
    Yamagami, Hitomi
    Yamamoto, Ayumi
    Minakawa, Yasuyuki
    Okamoto, Atsushi
    Kasamatsu, Atsushi
    Sakamoto, Yosuke
    Uzawa, Katsuhiro
    Takiguchi, Yuichi
    Tanzawa, Hideki
    ONCOLOGY REPORTS, 2017, 37 (04) : 2025 - 2032
  • [49] In vivo etoposide-resistant C6 glioma cell line: Significance of altered DNA topoisomerase II activity in multi-drug resistance
    Takuyu Taki
    Takanori Ohnishi
    Norio Arita
    Shoju Hiraga
    Toru Hayakawa
    Journal of Neuro-Oncology, 1998, 36 : 41 - 53
  • [50] In vivo etoposide-resistant C6 glioma cell line:: Significance of altered DNA topoisomerase II activity in multi-drug resistance
    Taki, T
    Ohnishi, T
    Arita, N
    Hiraga, S
    Hayakawa, T
    JOURNAL OF NEURO-ONCOLOGY, 1998, 36 (01) : 41 - 53