Truncation of the C-terminus domain of topoisomerase IIα enhances enzymatic activity and reduces drug sensitivity

被引：0
|
作者：
Chikamori, Kenichi
Andersen, Anni H.
Bukowski, Ronald M.
Ganapathi, Ram
Ganapathi, Mahrukh K.
机构：
[1] Cleveland Clin Fdn, Cleveland, OH 44195 USA
[2] Aarhus Univ, DK-8000 Aarhus C, Denmark
来源：
CANCER RESEARCH | 2006年 / 66卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1938
引用
收藏
页数：1
相关论文
共 50 条
  • [31] The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity
    Mancini, A
    Koch, A
    Stefan, M
    Niemann, H
    Tamura, T
    FEBS LETTERS, 2000, 482 (1-2) : 54 - 58
  • [32] C-terminal truncation and histidine-tagging of cytochrome c oxidase subunit II reveals the native processing site, shows involvement of the C-terminus in cytochrome c binding, and improves the assay for proton pumping
    Hiser, C
    Mills, DA
    Schall, M
    Ferguson-Miller, S
    BIOCHEMISTRY, 2001, 40 (06) : 1606 - 1615
  • [33] Inhibition of Kir2.1 channel activity by multiple amino acid substitutions at E303 location on C-terminus domain.
    Bajic, S
    Kawano, T
    Nakajima, Y
    Nakajima, S
    BIOPHYSICAL JOURNAL, 2003, 84 (02) : 78A - 79A
  • [34] Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells
    Oshiro, MM
    Landowski, TH
    Catlett-Falcone, R
    Hazlehurst, LA
    Huang, M
    Jove, R
    Dalton, WS
    CLINICAL CANCER RESEARCH, 2001, 7 (12) : 4262 - 4271
  • [35] Functional implications of C-terminus of TBX5 with high homology to C-terminal domain of yeast DNA-directed RNA polymerase II largest subunit
    Zhou Zhu-ren
    Gong Li-guo
    Geng Wen-qing
    Qiu Guang-rong
    Sun Kai-lai
    CHINESE MEDICAL JOURNAL, 2008, 121 (08) : 762 - 765
  • [36] Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
    Onoda, Akihisa
    Hosoya, Osamu
    Sano, Kuniaki
    Kiyama, Kazuko
    Kimura, Hiroshi
    Kawano, Shinji
    Furuta, Ryohei
    Miyaji, Mary
    Tsutsui, Ken
    Tsutsui, Kimiko M.
    NUCLEIC ACIDS RESEARCH, 2014, 42 (14) : 9005 - 9020
  • [37] Regulation of catalytic activity and nucleolar localization of rat DNA topoisomerase IIα through its C-terminal domain
    Yasuda, Kazushi
    Kato, Yuri
    Ikeda, Shogo
    Kawano, Shinji
    GENES & GENETIC SYSTEMS, 2020, 95 (06) : 291 - 302
  • [38] Limited proteolysis of rat phosphatidylinositol transfer protein by trypsin cleaves the C terminus, enhances binding to lipid vesicles, and reduces phospholipid transfer activity
    Tremblay, JM
    Helmkamp, GM
    Yarbrough, LR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (35) : 21075 - 21080
  • [39] Overexpression of the atypical protein kinase C ξ reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells
    Plo, I
    Hernandez, H
    Kohlhagen, G
    Lautier, D
    Pommier, Y
    Laurent, G
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (35) : 31407 - 31415
  • [40] DNA-binding activity of rat DNA topoisomerase II α C-terminal domain contributes to efficient DNA catenation in vitro
    Kawano, Shinji
    Kato, Yuri
    Okada, Natsumi
    Sano, Kuniaki
    Tsutsui, Ken
    Tsutsui, Kimiko M.
    Ikeda, Shogo
    JOURNAL OF BIOCHEMISTRY, 2016, 159 (03): : 363 - 369
12345