Asthma;
Lead poisoning;
Comorbidity;
Immunoregulation;
Environmental health disparities;
PREVALENCE;
D O I:
10.1016/j.envres.2010.11.007
中图分类号:
X [环境科学、安全科学];
学科分类号:
08 ;
0830 ;
摘要:
Objective: We sought to ascertain whether asthmatic children are more likely to have elevated blood lead levels (EBLLs), BLLs >= 10 mu g/dL, than non-asthmatic children. Household risk factors associated with both lead and asthma were examined. Method: We undertook a cross-sectional study involving children residing in mainly low-income and minority households in Michigan which were identified by the Statewide Systemic Tracking of Elevated Lead Levels and Remediation database (STELLAR) (n=356 children). Results: Of the 356 index children, 19% had EBLLs and 15% were doctor-diagnosed asthmatic. After adjusting for confounders known to be related to lead poisoning and/or asthma, association remained between asthmatic children and EBLL children (AOR: 5.17; 95% CI (1.25-21.37)). Conclusions: The results of our study show that asthmatic children are over 5 times more likely to have EBLLs than non-asthmatics (AOR: 5.17; 95% CI (1.25-21.37)). Intervention strategies designed to address lead poisoning prevention may be effective in reducing incidence of asthma. Further study is required. (C) 2010 Elsevier Inc. All rights reserved.
机构:
Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USAUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
Nriagu, Jerome
Martin, Joseph
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Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USAUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
Martin, Joseph
Smith, Pamela
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机构:
Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
Saginaw Cty Dept Publ Hlth, Hlth Homes & Lead Hazard Control Program, Saginaw, MI 48602 USAUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
Smith, Pamela
Socier, Deborah
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h-index: 0
机构:
Saginaw Cty Dept Publ Hlth, Hlth Homes & Lead Hazard Control Program, Saginaw, MI 48602 USAUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
机构:
Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Wayne State Univ, Merrill Palmer Skillman Inst, Detroit, MI 48202 USAWayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Dexter, Casey A.
Wong, Kristyn
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h-index: 0
机构:
Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Wayne State Univ, Merrill Palmer Skillman Inst, Detroit, MI 48202 USAWayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Wong, Kristyn
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机构:
Stacks, Ann M.
Beeghly, Marjorie
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机构:
Wayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Wayne State Univ, Merrill Palmer Skillman Inst, Detroit, MI 48202 USAWayne State Univ, Dept Psychol, Detroit, MI 48202 USA
Beeghly, Marjorie
Barnett, Douglas
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机构:
Wayne State Univ, Dept Psychol, Detroit, MI 48202 USAWayne State Univ, Dept Psychol, Detroit, MI 48202 USA
机构:
Univ Iowa, Coll Dent, Dept Operat Dent, Iowa City, IA 52242 USAUniv Iowa, Coll Dent, Dept Operat Dent, Iowa City, IA 52242 USA
Kolker, Justine L.
Yuan, Ying
论文数: 0引用数: 0
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机构:
Univ Texas Houston, Dept Biostat & Appl Math, MD Anderson Canc Ctr, Houston, TX USAUniv Iowa, Coll Dent, Dept Operat Dent, Iowa City, IA 52242 USA
Yuan, Ying
Burt, Brian A.
论文数: 0引用数: 0
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机构:
Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Dent, Ann Arbor, MI 48109 USAUniv Iowa, Coll Dent, Dept Operat Dent, Iowa City, IA 52242 USA
Burt, Brian A.
Sandretto, Anita M.
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机构:
Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USAUniv Iowa, Coll Dent, Dept Operat Dent, Iowa City, IA 52242 USA
Sandretto, Anita M.
Sohn, Woosung
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h-index: 0
机构:
Univ Michigan, Dept Cardiol, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Restorat Sci, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Endodont, Ann Arbor, MI 48109 USAUniv Iowa, Coll Dent, Dept Operat Dent, Iowa City, IA 52242 USA
Sohn, Woosung
Lang, Sylvia W.
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机构:
Univ Michigan, Inst Gerontol, Ann Arbor, MI 48109 USAUniv Iowa, Coll Dent, Dept Operat Dent, Iowa City, IA 52242 USA
Lang, Sylvia W.
Ismail, Amid I.
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h-index: 0
机构:
Univ Michigan, Dept Cardiol, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Restorat Sci, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Endodont, Ann Arbor, MI 48109 USAUniv Iowa, Coll Dent, Dept Operat Dent, Iowa City, IA 52242 USA