Reversing Age-Related Decline in Working Memory

被引：10
|
作者：
Mendelsohn, Andrew R. [1 ,2 ]
Larrick, James W. [1 ,2 ]
机构：
[1] Panorama Res Inst, Sunnyvale, CA 94089 USA
[2] Regenerat Sci Inst, Sunnyvale, CA 94089 USA
来源：
REJUVENATION RESEARCH | 2011年 / 14卷 / 05期
关键词：
LONG-TERM POTENTIATION; PREFRONTAL CORTEX; IMPAIRMENT; GUANFACINE;
D O I：
10.1089/rej.2011.1247
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Higher cognitive functions, such as working memory and the ability to focus attention, decline as people age. Recently, it has been reported that decline in working memory in aging rhesus monkeys correlates with the loss of activity of a specific set of neurons in the prefrontal cortex during a delay following a learning cue. The activity of these neurons can be rescued by stimulating alpha-2 adrenergic receptors, inhibiting cyclic adenosine monophosphate (cAMP) signaling, or closing potassium channels that are known to inhibit firing and synaptic connectivity. Agents that stimulate neurons expressing alpha-2 adrenergic receptors may prove useful in treating working memory loss in humans.
引用
收藏
页码：557 / 559
页数：3
相关论文
共 50 条
  • [31] THE INTERACTION BETWEEN MEMORY TRACE AND MEMORY JUDGMENT IN AGE-RELATED DECLINE
    Guillaume, Fabrice
    Tison, Cecile
    Marzouki, Yousri
    [J]. EXPERIMENTAL AGING RESEARCH, 2015, 41 (05) : 510 - 533
  • [32] Age-related deficits in component processes of working memory
    Gazzaley, Adam
    Sheridan, Margaret A.
    Cooney, Jeffrey W.
    D'Esposito, Mark
    [J]. NEUROPSYCHOLOGY, 2007, 21 (05) : 532 - 539
  • [33] Age-related differences in executive control of working memory
    Roee Holtzer
    Yaakov Stern
    Brian C. Rakitin
    [J]. Memory & Cognition, 2004, 32 : 1333 - 1345
  • [34] Age-Related Changes in Verbal Working Memory Strategies
    Chevalere, Johann
    Lemaire, Patrick
    Camos, Valerie
    [J]. EXPERIMENTAL AGING RESEARCH, 2020, 46 (02) : 93 - 127
  • [35] Directed forgetting in working memory:: Age-related differences
    Andrés, P
    Van der Linden, M
    Parmentier, FBR
    [J]. MEMORY, 2004, 12 (02) : 248 - 256
  • [36] Age-related differences in executive control of working memory
    Holtzer, R
    Stern, Y
    Rakitin, BC
    [J]. MEMORY & COGNITION, 2004, 32 (08) : 1333 - 1345
  • [37] AGE-RELATED DIFFERENCES IN UPDATING WORKING-MEMORY
    VANDERLINDEN, M
    BREDART, S
    BEERTEN, A
    [J]. BRITISH JOURNAL OF PSYCHOLOGY, 1994, 85 : 145 - 152
  • [38] Age-related differences in working memory updating components
    Linares, Rocio
    Teresa Bajo, M.
    Pelegrina, Santiago
    [J]. JOURNAL OF EXPERIMENTAL CHILD PSYCHOLOGY, 2016, 147 : 39 - 52
  • [39] Age-Related Decline in Visual Working Memory: The Effect of Nontarget Objects During a Delayed Estimation Task
    Tas, A. Caglar
    Costello, Matthew C.
    Buss, Aaron T.
    [J]. PSYCHOLOGY AND AGING, 2020, 35 (04) : 565 - 577
  • [40] Social housing protects against age-related working memory decline independently of physical enrichment in rats
    Templer, Victoria L.
    Wise, Taylor B.
    Heimer-McGinn, Victoria R.
    [J]. NEUROBIOLOGY OF AGING, 2019, 75 : 117 - 125
12345