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Reversing Age-Related Decline in Working Memory

被引：10
|
作者：
Mendelsohn, Andrew R. [1 ,2 ]
Larrick, James W. [1 ,2 ]
机构：
[1] Panorama Res Inst, Sunnyvale, CA 94089 USA
[2] Regenerat Sci Inst, Sunnyvale, CA 94089 USA
来源：
REJUVENATION RESEARCH | 2011年 / 14卷 / 05期
关键词：
LONG-TERM POTENTIATION; PREFRONTAL CORTEX; IMPAIRMENT; GUANFACINE;
D O I：
10.1089/rej.2011.1247
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Higher cognitive functions, such as working memory and the ability to focus attention, decline as people age. Recently, it has been reported that decline in working memory in aging rhesus monkeys correlates with the loss of activity of a specific set of neurons in the prefrontal cortex during a delay following a learning cue. The activity of these neurons can be rescued by stimulating alpha-2 adrenergic receptors, inhibiting cyclic adenosine monophosphate (cAMP) signaling, or closing potassium channels that are known to inhibit firing and synaptic connectivity. Agents that stimulate neurons expressing alpha-2 adrenergic receptors may prove useful in treating working memory loss in humans.
引用
收藏
页码：557 / 559
页数：3
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