Synthesis of 13C-labeled patulin [4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one] to be used as internal standard in a stable isotope dilution assay

被引：24

作者：

Rychlik, M ^{[1
]}

Schieberle, P ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Lebensmittelchem, D-85748 Garching, Germany

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1998年 / 46卷 / 12期

关键词：

atmospheric pressure chemical ionization (APCI); electrospray ionization (ESI); patulin; stable isotope dilution assay;

D O I：

10.1021/jf980506p

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

A synthetic route was established for the preparation of [C-13(2)]-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)- one (patulin) to be used in a stable isotope dilution assay. Mass spectral analyses were performed using electron impact ionization (EI), negative electrospray ionization (ESI), collision-induced dissociation (CID), and atmospheric pressure ionization. Fragmentation routes in the EI mode and in CID were concluded and compared with each other.

引用

页码：5163 / 5169

页数：7

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