Synthesis of 13C-labeled patulin [4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one] to be used as internal standard in a stable isotope dilution assay

被引：24
|
作者：
Rychlik, M [1 ]
Schieberle, P [1 ]
机构：
[1] Tech Univ Munich, Inst Lebensmittelchem, D-85748 Garching, Germany
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1998年 / 46卷 / 12期
关键词：
atmospheric pressure chemical ionization (APCI); electrospray ionization (ESI); patulin; stable isotope dilution assay;
D O I：
10.1021/jf980506p
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
A synthetic route was established for the preparation of [C-13(2)]-4-hydroxy-4H-furo[3,2-c]pyran-2(6H)- one (patulin) to be used in a stable isotope dilution assay. Mass spectral analyses were performed using electron impact ionization (EI), negative electrospray ionization (ESI), collision-induced dissociation (CID), and atmospheric pressure ionization. Fragmentation routes in the EI mode and in CID were concluded and compared with each other.
引用
收藏
页码：5163 / 5169
页数：7
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