PENICILLIN G PRODUCTION BY INDUSTRIAL STRAINS OF PENICILLIUM CHRYSOGENUM

被引：0
|
作者：
Kurzatkowski, Wieslaw [1 ]
Staniszewska, Monika [1 ]
Bondaryk, Malgorzata [1 ]
Gebska-Kuczerowska, Anita [2 ]
机构：
[1] Natl Inst Hyg, Natl Inst Publ Hlth, Independent Lab Streptomyces & Fungi Imperfecti, PL-00791 Warsaw, Poland
[2] Natl Inst Hyg, Natl Inst Publ Hlth, Dept Hlth Promot & Postgrad Educ, PL-00791 Warsaw, Poland
来源：
POSTEPY MIKROBIOLOGII | 2014年 / 53卷 / 04期
关键词：
biosynthesis; penicillin G; P; chrysogenum; peroxisomes; ISOPENICILLIN-N-ACYLTRANSFERASE; BETA-LACTAM ANTIBIOTICS; ENDOPLASMIC-RETICULUM; FILAMENTOUS FUNGI; PEROXISOME BIOGENESIS; ACID ACYLTRANSFERASE; BIOSYNTHESIS; COMPARTMENTALIZATION; LOCALIZATION; MICROBODIES;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The role of peroxisomes in penicillin G production by industrial strains of Penicillium chrysogenum is discussed. Penicillin G biosynthesis is a compartmentalized process mainly located in sub-apical productive vacuolated non-growing cells of the mycelium. The cellular localization of the pathway of penicillin G biosynthesis is presented, including some putative enzymatic and transport steps of precursors, intermediates, side-products and end-products. A phenylacetic acid detoxification hypothesis of penicillin G biosynthesis is suggested.
引用
收藏
页码：366 / 370
页数：5
相关论文
共 50 条
  • [41] PENICILLIN ACYLASE ACTIVITY OF PENICILLIUM CHRYSOGENUM
    ERICKSON, RC
    BENNETT, RE
    APPLIED MICROBIOLOGY, 1965, 13 (05) : 738 - &
  • [42] Impact of the Penicillium chrysogenum genome on industrial production of metabolites
    van den Berg, Marco Alexander
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 92 (01) : 45 - 53
  • [43] In vivo transport of the intermediates of the penicillin biosynthetic pathway in tailored strains of Penicillium chrysogenum
    Garcia-Estrada, Carlos
    Vaca, Inmaculada
    Lamas-Maceiras, Monica
    Francisco Martin, Juan
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2007, 76 (01) : 169 - 182
  • [44] SELECTION OF STRAINS OF PENICILLIUM-CHRYSOGENUM WITH REDUCED PENICILLIN YIELDS IN CONTINUOUS CULTURES
    RIGHELATO, RC
    JOURNAL OF APPLIED CHEMISTRY AND BIOTECHNOLOGY, 1976, 26 (03): : 153 - 159
  • [45] Effect of Gamma-Rays on the Growth and Penicillin Production of Penicillium chrysogenum
    Aljeldah, Mohammed M.
    El-Sayyad, Hosam
    Elhadi, Nasreldin
    Rabaan, Ali A.
    JOURNAL OF PURE AND APPLIED MICROBIOLOGY, 2019, 13 (02): : 779 - 788
  • [46] PENICILLIUM-CHRYSOGENUM, ITS GOLGI-APPARATUS AND PENICILLIN PRODUCTION
    KURYLOWICZ, W
    KURZATKOWSKI, W
    ACTA MICROBIOLOGICA HUNGARICA, 1988, 35 (02): : 124 - 124
  • [47] IMPAIRED PENICILLIN PRODUCTION IN LYSINE REGULATORY MUTANTS OF PENICILLIUM-CHRYSOGENUM
    MASUREKAR, PS
    DEMAIN, AL
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1974, 6 (03) : 366 - 368
  • [48] Comparative Metabolomic Study of Penicillium chrysogenum During Pilot and Industrial Penicillin Fermentations
    Ming-Zhu Ding
    Hua Lu
    Jing-Sheng Cheng
    Yao Chen
    Jing Jiang
    Bin Qiao
    Bing-Zhi Li
    Ying-Jin Yuan
    Applied Biochemistry and Biotechnology, 2012, 168 : 1223 - 1238
  • [49] PRODUCTION OF PENICILLIN WITH WASTE MYCELIUM OF PENICILLIUM CHRYSOGENUM AS SOLE SOURCE OF NITROGEN
    GHOSH, D
    GANGULI, BN
    APPLIED MICROBIOLOGY, 1961, 9 (03) : 252 - &
  • [50] HETEROKARYON STUDIES AND GENETIC CONTROL OF PENICILLIN AND CHRYSOGENIN PRODUCTION IN PENICILLIUM CHRYSOGENUM
    MACDONALD, KD
    HUTCHINSON, JM
    GILLETT, WA
    JOURNAL OF GENERAL MICROBIOLOGY, 1963, 33 (03): : 375 - +
12345