PENICILLIN G PRODUCTION BY INDUSTRIAL STRAINS OF PENICILLIUM CHRYSOGENUM

被引：0
|
作者：
Kurzatkowski, Wieslaw [1 ]
Staniszewska, Monika [1 ]
Bondaryk, Malgorzata [1 ]
Gebska-Kuczerowska, Anita [2 ]
机构：
[1] Natl Inst Hyg, Natl Inst Publ Hlth, Independent Lab Streptomyces & Fungi Imperfecti, PL-00791 Warsaw, Poland
[2] Natl Inst Hyg, Natl Inst Publ Hlth, Dept Hlth Promot & Postgrad Educ, PL-00791 Warsaw, Poland
来源：
POSTEPY MIKROBIOLOGII | 2014年 / 53卷 / 04期
关键词：
biosynthesis; penicillin G; P; chrysogenum; peroxisomes; ISOPENICILLIN-N-ACYLTRANSFERASE; BETA-LACTAM ANTIBIOTICS; ENDOPLASMIC-RETICULUM; FILAMENTOUS FUNGI; PEROXISOME BIOGENESIS; ACID ACYLTRANSFERASE; BIOSYNTHESIS; COMPARTMENTALIZATION; LOCALIZATION; MICROBODIES;
D O I：
暂无
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The role of peroxisomes in penicillin G production by industrial strains of Penicillium chrysogenum is discussed. Penicillin G biosynthesis is a compartmentalized process mainly located in sub-apical productive vacuolated non-growing cells of the mycelium. The cellular localization of the pathway of penicillin G biosynthesis is presented, including some putative enzymatic and transport steps of precursors, intermediates, side-products and end-products. A phenylacetic acid detoxification hypothesis of penicillin G biosynthesis is suggested.
引用
收藏
页码：366 / 370
页数：5
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