Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury)

被引：14
|
作者：
Raji-amirhasani, Alireza [1 ]
Khaksari, Mohammad [1 ]
Darvishzadeh Mahani, Fatemeh [2 ]
Hajializadeh, Zahra [3 ]
机构：
[1] Kerman Univ Med Sci, Endocrinol & Metab Res Ctr, Kerman, Iran
[2] Kerman Univ Med Sci, Cardiovasc Res Ctr, Kerman, Iran
[3] Kerman Univ Med Sci, Inst Neuropharmacol, Physiol Res Ctr, Kerman, Iran
来源：
CLINICAL AND EXPERIMENTAL NEPHROLOGY | 2021年 / 25卷 / 08期
关键词：
Acute kidney injury; SIRT1; Activators of SIRT1; Histone acetylation; NF-KAPPA-B; RENAL ISCHEMIA/REPERFUSION INJURY; TUBULAR EPITHELIAL-CELLS; INDUCED CD40 EXPRESSION; COLLECTING DUCT CELLS; EXTRACELLULAR VESICLES; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; ANTIOXIDATIVE PATHWAY; INDUCED NEPHROPATHY;
D O I：
10.1007/s10157-021-02057-0
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Acute kidney injury (AKI) is a complex disorder and a clinical condition characterized by acute reduction in renal function. If AKI is not treated, it can lead to chronic kidney disease, which is associated with a high risk of death. SIRT1 (silent information regulator 1) is an NAD-dependent deacetylase. This enzyme is responsible for the processes of DNA repair or recombination, chromosomal stability, and gene transcription. This enzyme also plays a protective role in many diseases, including AKI. In this study, we review the mechanisms that mediate the protective effects of SIRT1 on AKI, including SIRT1 activators.
引用
收藏
页码：807 / 821
页数：15
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