Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury)

被引：14

作者：

Raji-amirhasani, Alireza ^{[1
]}

Khaksari, Mohammad ^{[1
]}

Darvishzadeh Mahani, Fatemeh ^{[2
]}

Hajializadeh, Zahra ^{[3
]}

机构：

[1] Kerman Univ Med Sci, Endocrinol & Metab Res Ctr, Kerman, Iran

[2] Kerman Univ Med Sci, Cardiovasc Res Ctr, Kerman, Iran

[3] Kerman Univ Med Sci, Inst Neuropharmacol, Physiol Res Ctr, Kerman, Iran

来源：

CLINICAL AND EXPERIMENTAL NEPHROLOGY | 2021年 / 25卷 / 08期

关键词：

Acute kidney injury; SIRT1; Activators of SIRT1; Histone acetylation; NF-KAPPA-B; RENAL ISCHEMIA/REPERFUSION INJURY; TUBULAR EPITHELIAL-CELLS; INDUCED CD40 EXPRESSION; COLLECTING DUCT CELLS; EXTRACELLULAR VESICLES; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; ANTIOXIDATIVE PATHWAY; INDUCED NEPHROPATHY;

D O I：

10.1007/s10157-021-02057-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Acute kidney injury (AKI) is a complex disorder and a clinical condition characterized by acute reduction in renal function. If AKI is not treated, it can lead to chronic kidney disease, which is associated with a high risk of death. SIRT1 (silent information regulator 1) is an NAD-dependent deacetylase. This enzyme is responsible for the processes of DNA repair or recombination, chromosomal stability, and gene transcription. This enzyme also plays a protective role in many diseases, including AKI. In this study, we review the mechanisms that mediate the protective effects of SIRT1 on AKI, including SIRT1 activators.

引用

页码：807 / 821

页数：15

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