Suzuki Coupling of Amides via Palladium-Catalyzed C-N Cleavage of N-Acylsaccharins

被引：72
|
作者：
Wu, Hongxiang [1 ]
Li, Yue [1 ]
Cui, Ming [1 ]
Jian, Junsheng [1 ]
Zeng, Zhuo [1 ,2 ]
机构：
[1] South China Normal Univ, Coll Chem & Environm, Guangzhou 510006, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 23期
基金：
中国国家自然科学基金;
关键词：
N-acylsaccharins; C-N bond cleavage; ketones; Suzuki coupling; twisted amides; BOND ACTIVATION; ARYLBORONIC ACIDS; KETONE SYNTHESIS; CARBONYL SOURCE; TWISTED AMIDES; FUNCTIONALIZATION; ARYLKETONES; PYRROLES; INDOLES; ESTERS;
D O I：
10.1002/adsc.201600555
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A palladium-catalyzed cross-coupling of activated amides with arylboronic acids has been developed via C-N bond cleavage. This approach demonstrated high tolerance to a variety of alkyl, aryl, heterocyclic and vinyl substituents. Unsymmetrical ketones could be achieved in excellent yield under mild conditions with 1% catalyst loadings.
引用
收藏
页码：3876 / 3880
页数：5
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