Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C-N Bond Cleavage

被引：4
|
作者：
He, Zhanyu [1 ]
Yan, Chu [1 ]
Zhang, Mei [1 ]
Irfan, Majeed [1 ]
Wang, Zijia [1 ]
Zeng, Zhuo [1 ,2 ]
机构：
[1] South China Normal Univ, Sch Chem, Guangzhou 510006, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2022年 / 54卷 / 03期
基金：
中国国家自然科学基金;
关键词：
desulfurative Hiyama coupling; CuF2; activator; thiourea; selective C-N bond cleavage; amide; TRANSAMIDATION;
D O I：
10.1055/s-0040-1720907
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed Hiyama coupling of active thioureas via selective C-N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF2 as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.
引用
收藏
页码：705 / 710
页数：6
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