Feasibility of Image-Guided Radiotherapy and Concurrent Chemotherapy for Locally Advanced Nonsmall Cell Lung Cancer

被引：6

作者：

Nguyen, Nam P. ^{[1
]}

Kratz, Sarah ^{[2
]}

Chi, Alexander ^{[3
]}

Vock, Jacqueline ^{[4
]}

Vos, Paul ^{[5
]}

Shen, Wei ^{[6
]}

Vincent, Vinh-Hung ^{[6
]}

Ewell, Lars ^{[7
]}

Jang, Siyoung ^{[8
]}

Altdorfer, Gabor ^{[9
]}

Karlsson, Ulf ^{[10
]}

Godinez, Juan ^{[11
]}

Woods, William ^{[12
]}

Dutta, Suresh ^{[13
]}

Ampil, Fred ^{[14
,15
]}

机构：

[1] Howard Univ, Dept Radiat Oncol, Washington, DC 20059 USA

[2] Univ Arizona, Div Hematol Oncol, Tucson, AZ 85721 USA

[3] W Virginia Univ, Dept Radiat Oncol, Morgantown, WV 26506 USA

[4] Lindenhofspital, Dept Radiat Oncol, Bern, Switzerland

[5] E Carolina Univ, Dept Biostat, Greenville, NC USA

[6] Univ Arizona, Div Pulm Med, Tucson, AZ USA

[7] Martinique Hosp Univ, Dept Radiat Oncol, Fort De France, Martinique, France

[8] Hampton Univ, Proto Inst, Dept Radiat Oncol, Hampton, VA 23668 USA

[9] Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85721 USA

[10] Camden Clark Med Ctr, Dept Radiat Oncol, Parkersburg, WV USA

[11] Marshfield Clin Fdn Med Res & Educ, Dept Radiat Oncol, Marshfield, WI USA

[12] Rochester Gen Hosp, Dept Radiat Oncol, Rochester, NY 14621 USA

[13] Richard A Henson Canc Inst, Dept Radiat Oncol, Salisbury, MD USA

[14] Med & Radiat Oncol PA, Dept Radiat Oncol, San Antonio, TX USA

[15] Louisiana State Univ, Dept Radiat Oncol, Shreveport, LA 71105 USA

来源：

CANCER INVESTIGATION | 2015年 / 33卷 / 03期

关键词：

NSCLC; Locally advanced; Chemoradiation; IGRT; RANDOMIZED PHASE-II; INTENSITY-MODULATED RADIOTHERAPY; RADIATION-THERAPY; THORACIC RADIOTHERAPY; DOSE-ESCALATION; NECK-CANCER; CHEMORADIOTHERAPY; TOMOTHERAPY; CARCINOMA; CISPLATIN;

D O I：

10.3109/07357907.2014.1001896

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A retrospective review of 32 patients with stage III nonsmall cell lung cancer who underwent chemoradiation with image-guided radiotherapy (IGRT) was recorded. Acute grade 3-4 hematologic and esophageal toxicities developed in 6 and 13 patients respectively. At a median follow-up of 14.5 months, only one patient developed grade 3 pneumonitis. The median survival was estimated to be 17 months. Five patients (15%) developed loco-regional recurrences, and 17 patients (53%) distant metastases. Grade 3-4 toxicities remained significant during chemoradiation with IGRT. However, the reduced rate of severe pneumonitis despite a high tumor dose is encouraging and needs to be investigated in future prospective studies.

引用

页码：53 / 60

页数：8

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