Feasibility of Image-Guided Radiotherapy and Concurrent Chemotherapy for Locally Advanced Nonsmall Cell Lung Cancer

被引：6

作者：

Nguyen, Nam P. ^{[1
]}

Kratz, Sarah ^{[2
]}

Chi, Alexander ^{[3
]}

Vock, Jacqueline ^{[4
]}

Vos, Paul ^{[5
]}

Shen, Wei ^{[6
]}

Vincent, Vinh-Hung ^{[6
]}

Ewell, Lars ^{[7
]}

Jang, Siyoung ^{[8
]}

Altdorfer, Gabor ^{[9
]}

Karlsson, Ulf ^{[10
]}

Godinez, Juan ^{[11
]}

Woods, William ^{[12
]}

Dutta, Suresh ^{[13
]}

Ampil, Fred ^{[14
,15
]}

机构：

[1] Howard Univ, Dept Radiat Oncol, Washington, DC 20059 USA

[2] Univ Arizona, Div Hematol Oncol, Tucson, AZ 85721 USA

[3] W Virginia Univ, Dept Radiat Oncol, Morgantown, WV 26506 USA

[4] Lindenhofspital, Dept Radiat Oncol, Bern, Switzerland

[5] E Carolina Univ, Dept Biostat, Greenville, NC USA

[6] Univ Arizona, Div Pulm Med, Tucson, AZ USA

[7] Martinique Hosp Univ, Dept Radiat Oncol, Fort De France, Martinique, France

[8] Hampton Univ, Proto Inst, Dept Radiat Oncol, Hampton, VA 23668 USA

[9] Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85721 USA

[10] Camden Clark Med Ctr, Dept Radiat Oncol, Parkersburg, WV USA

[11] Marshfield Clin Fdn Med Res & Educ, Dept Radiat Oncol, Marshfield, WI USA

[12] Rochester Gen Hosp, Dept Radiat Oncol, Rochester, NY 14621 USA

[13] Richard A Henson Canc Inst, Dept Radiat Oncol, Salisbury, MD USA

[14] Med & Radiat Oncol PA, Dept Radiat Oncol, San Antonio, TX USA

[15] Louisiana State Univ, Dept Radiat Oncol, Shreveport, LA 71105 USA

来源：

CANCER INVESTIGATION | 2015年 / 33卷 / 03期

关键词：

NSCLC; Locally advanced; Chemoradiation; IGRT; RANDOMIZED PHASE-II; INTENSITY-MODULATED RADIOTHERAPY; RADIATION-THERAPY; THORACIC RADIOTHERAPY; DOSE-ESCALATION; NECK-CANCER; CHEMORADIOTHERAPY; TOMOTHERAPY; CARCINOMA; CISPLATIN;

D O I：

10.3109/07357907.2014.1001896

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A retrospective review of 32 patients with stage III nonsmall cell lung cancer who underwent chemoradiation with image-guided radiotherapy (IGRT) was recorded. Acute grade 3-4 hematologic and esophageal toxicities developed in 6 and 13 patients respectively. At a median follow-up of 14.5 months, only one patient developed grade 3 pneumonitis. The median survival was estimated to be 17 months. Five patients (15%) developed loco-regional recurrences, and 17 patients (53%) distant metastases. Grade 3-4 toxicities remained significant during chemoradiation with IGRT. However, the reduced rate of severe pneumonitis despite a high tumor dose is encouraging and needs to be investigated in future prospective studies.

引用

页码：53 / 60

页数：8

共 50 条

[21] NEOADJUVANT CHEMOTHERAPY OF LOCALLY ADVANCED NONSMALL CELL LUNG-CANCER
PUJOL, JL
LECHEVALIER, T
RAY, P
GAUTIER, V
ROUANET, P
ARRIAGADA, R
GRUNENWALD, D
MICHEL, FB
[J]. LUNG CANCER, 1995, 12 : S107 - S118
[22] Image-guided radiotherapy in lung cancer
Aboudaram, A.
Khalifa, J.
Massabeau, C.
Sirrion, L.
Henni, A. Hadj
Thureau, S.
[J]. CANCER RADIOTHERAPIE, 2018, 22 (6-7): : 602 - 607
[23] Image-guided adaptive radiotherapy in patients with locally advanced non-small cell lung cancer: the art of PET
Grootjans, Willem
de Geus-Oei, Lioe-Fee
Bussink, Johan
[J]. QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2018, 62 (04): : 369 - 384
[24] Feasibility of Image-guided Radiotherapy Based on Tomotherapy for the Treatment of Locally Advanced Anal Carcinoma
Nguyen, Nam P.
Vock, Jacqueline
Sroka, Thomas
Khan, Rihan
Jang, Siyoung
Chi, Alexander
Betz, Michael
Ewell, Lars
Cohen, Deirdre
Vo, Richard P.
Mills, Melissa
Vinh-Hung, Vincent
[J]. ANTICANCER RESEARCH, 2011, 31 (12) : 4393 - 4396
[25] Impact of Different Image-guided Protocols on Geometric Accuracy of Radiotherapy for Locally-advanced Lung Cancer
Higgins, J. A.
Bezjak, A.
Hope, A.
Panzarella, T.
Li, W.
Craig, T.
Brade, A.
Sun, A.
Cho, J.
Bissonnette, J.
[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 75 (03): : S98 - S98
[26] Image-guided intensity-modulated radiotherapy for patients with locally advanced gastric cancer: a clinical feasibility study
Harun Badakhshi
Arne Gruen
Reinhold Graf
Dirk Boehmer
Volker Budach
[J]. Gastric Cancer, 2014, 17 : 537 - 541
[27] Image-guided intensity-modulated radiotherapy for patients with locally advanced gastric cancer: a clinical feasibility study
Badakhshi, Harun
Gruen, Arne
Graf, Reinhold
Boehmer, Dirk
Budach, Volker
[J]. GASTRIC CANCER, 2014, 17 (03) : 537 - 541
[28] Feasibility of Intensity-Modulated and Image-Guided Radiotherapy for Functional Organ Preservation in Locally Advanced Laryngeal Cancer
Nguyen, Nam P.
Chi, Alexander
Betz, Michael
Almeida, Fabio
Vos, Paul
Davis, Rick
Slane, Benjamin
Ceizyk, Misty
Abraham, Dave
Smith-Raymond, Lexie
Stevie, Michelle
Jang, Siyoung
Gelumbauskas, Steven
Vincent Vinh-Hung
[J]. PLOS ONE, 2012, 7 (08):
[29] COMBINED CHEMOTHERAPY AND RADIATION IN LOCALLY ADVANCED NONSMALL CELL LUNG-CANCER
BELANI, CP
AISNER, J
[J]. SEMINARS IN ONCOLOGY, 1994, 21 (03) : 79 - 90
[30] Effectiveness of image-guided radiotherapy for locally advanced esophageal squamous cell carcinoma patients treated with definitive concurrent chemoradiotherapy
Kuo, Yao-Hung
Fang, Hsin-Yuan
Lin, Yu-Sen
Lein, Ming-Yu
Yang, Chi-Ying
Ho, Shih-Chi
Li, Chia-Chin
Chien, Chun-Ru
[J]. THORACIC CANCER, 2020, 11 (01) : 113 - 119

← 1 2 3 4 5 →