Feasibility of Image-Guided Radiotherapy and Concurrent Chemotherapy for Locally Advanced Nonsmall Cell Lung Cancer

被引：6

作者：

Nguyen, Nam P. ^{[1
]}

Kratz, Sarah ^{[2
]}

Chi, Alexander ^{[3
]}

Vock, Jacqueline ^{[4
]}

Vos, Paul ^{[5
]}

Shen, Wei ^{[6
]}

Vincent, Vinh-Hung ^{[6
]}

Ewell, Lars ^{[7
]}

Jang, Siyoung ^{[8
]}

Altdorfer, Gabor ^{[9
]}

Karlsson, Ulf ^{[10
]}

Godinez, Juan ^{[11
]}

Woods, William ^{[12
]}

Dutta, Suresh ^{[13
]}

Ampil, Fred ^{[14
,15
]}

机构：

[1] Howard Univ, Dept Radiat Oncol, Washington, DC 20059 USA

[2] Univ Arizona, Div Hematol Oncol, Tucson, AZ 85721 USA

[3] W Virginia Univ, Dept Radiat Oncol, Morgantown, WV 26506 USA

[4] Lindenhofspital, Dept Radiat Oncol, Bern, Switzerland

[5] E Carolina Univ, Dept Biostat, Greenville, NC USA

[6] Univ Arizona, Div Pulm Med, Tucson, AZ USA

[7] Martinique Hosp Univ, Dept Radiat Oncol, Fort De France, Martinique, France

[8] Hampton Univ, Proto Inst, Dept Radiat Oncol, Hampton, VA 23668 USA

[9] Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85721 USA

[10] Camden Clark Med Ctr, Dept Radiat Oncol, Parkersburg, WV USA

[11] Marshfield Clin Fdn Med Res & Educ, Dept Radiat Oncol, Marshfield, WI USA

[12] Rochester Gen Hosp, Dept Radiat Oncol, Rochester, NY 14621 USA

[13] Richard A Henson Canc Inst, Dept Radiat Oncol, Salisbury, MD USA

[14] Med & Radiat Oncol PA, Dept Radiat Oncol, San Antonio, TX USA

[15] Louisiana State Univ, Dept Radiat Oncol, Shreveport, LA 71105 USA

来源：

CANCER INVESTIGATION | 2015年 / 33卷 / 03期

关键词：

NSCLC; Locally advanced; Chemoradiation; IGRT; RANDOMIZED PHASE-II; INTENSITY-MODULATED RADIOTHERAPY; RADIATION-THERAPY; THORACIC RADIOTHERAPY; DOSE-ESCALATION; NECK-CANCER; CHEMORADIOTHERAPY; TOMOTHERAPY; CARCINOMA; CISPLATIN;

D O I：

10.3109/07357907.2014.1001896

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A retrospective review of 32 patients with stage III nonsmall cell lung cancer who underwent chemoradiation with image-guided radiotherapy (IGRT) was recorded. Acute grade 3-4 hematologic and esophageal toxicities developed in 6 and 13 patients respectively. At a median follow-up of 14.5 months, only one patient developed grade 3 pneumonitis. The median survival was estimated to be 17 months. Five patients (15%) developed loco-regional recurrences, and 17 patients (53%) distant metastases. Grade 3-4 toxicities remained significant during chemoradiation with IGRT. However, the reduced rate of severe pneumonitis despite a high tumor dose is encouraging and needs to be investigated in future prospective studies.

引用

页码：53 / 60

页数：8

共 50 条

[1] FEASIBILITY OF IMAGE-GUIDED RADIOTHERAPY AND CONCURRENT CHEMOTHERAPY FOR LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER
Nguyen, Nam P.
Kratz, Sarah
Chi, Alexander
Vock, Jacqueline
Vos, Paul
Shen, Wei
Vinh-Hung, Vincent
Ewell, Lars
Jang, Siyoung
Altdorfer, Gabor
Karlsson, Ulf
Godinez, Juan
Woods, William
Dutta, Suresh
Ampil, Fred
[J]. ANTICANCER RESEARCH, 2014, 34 (10) : 6081 - 6081
[2] Effectiveness of image-guided radiotherapy for locally advanced lung cancer patients treated with definitive concurrent chemoradiotherapy
Liang, Ji-An
Tu, Chih-Yen
Hsia, Te-Chun
Fang, Hsin-Yuan
Li, Chia-Chin
Chien, Chun-Ru
[J]. THORACIC CANCER, 2020, 11 (09) : 2639 - 2649
[3] Feasibility of Image-Guided Radiotherapy for Elderly Patients with Locally Advanced Rectal Cancer
Nguyen, Nam P.
Ceizyk, Misty
Vock, Jacqueline
Vos, Paul
Chi, Alexander
Vincent Vinh-Hung
Pugh, Judy
Khan, Rihan
Christina Truong
Albala, Gabby
Locke, Angela
Karlsson, Ulf
Gelumbauskas, Steve
Smith-Raymond, Lexie
[J]. PLOS ONE, 2013, 8 (08):
[4] SCHEDULING OF CHEMOTHERAPY AND RADIOTHERAPY IN LOCALLY ADVANCED NONSMALL CELL LUNG-CANCER
BISHOP, JF
[J]. LUNG CANCER, 1995, 12 : S53 - S61
[5] CONCURRENT CHEMOTHERAPY (CT) AND RADIOTHERAPY (RT) IN LOCALLY ADVANCED NONSMALL CELL LUNG-CANCER (NSCLC) - A REVIEW
MIRIMANOFF, RO
[J]. LUNG CANCER, 1994, 11 : S79 - S99
[6] Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer
Nguyen, Nam P.
Jang, Siyoung
Vock, Jacqueline
Vincent Vinh-Hung
Chi, Alexander
Vos, Paul
Pugh, Judith
Vo, Richard A.
Ceizyk, Misty
Desai, Anand
Smith-Raymond, Lexie
[J]. BMC CANCER, 2014, 14
[7] Feasibility of Tomotherapy-Based Image-Guided Radiotherapy for Locally Advanced Oropharyngeal Cancer
Nguyen, Nam P.
Ceizyk, Misty
Vos, Paul
Betz, Michael
Chi, Alexander
Almeida, Fabio
Davis, Rick
Slane, Benjamin
Gelumbauskas, Steven
Smith-Raymond, Lexie
Abraham, Dave
Stevie, Michelle
Jang, Siyoung
Vinh-Hung, Vincent
[J]. PLOS ONE, 2013, 8 (03):
[8] Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer
Nam P Nguyen
Siyoung Jang
Jacqueline Vock
Vincent Vinh-Hung
Alexander Chi
Paul Vos
Judith Pugh
Richard A Vo
Misty Ceizyk
Anand Desai
Lexie Smith-Raymond
[J]. BMC Cancer, 14
[9] Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma
Pei-Wei Shueng
Bing-Jie Shen
Le-Jung Wu
Li-Jen Liao
Chi-Huang Hsiao
Yu-Chin Lin
Po-Wen Cheng
Wu-Chia Lo
Yee-Min Jen
Chen-Hsi Hsieh
[J]. Radiation Oncology, 6
[10] Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma
Shueng, Pei-Wei
Shen, Bing-Jie
Wu, Le-Jung
Liao, Li-Jen
Hsiao, Chi-Huang
Lin, Yu-Chin
Cheng, Po-Wen
Lo, Wu-Chia
Jen, Yee-Min
Hsieh, Chen-Hsi
[J]. RADIATION ONCOLOGY, 2011, 6

← 1 2 3 4 5 →