Alarming dendritic cells for Th2 induction

被引：125
|
作者：
MacDonald, Andrew S. [1 ]
Maizels, Rick M. [1 ]
机构：
[1] Univ Edinburgh, Inst Immunol & Infect Res, Ashworth Lab, Edinburgh EH9 3JT, Midlothian, Scotland
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 01期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
D O I：
10.1084/jem.20072665
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.
引用
收藏
页码：13 / 17
页数：5
相关论文
共 50 条
  • [41] Plasmacytoid dendritic cells suppress Th2 responses induced by epicutaneous sensitization
    Lin, Jing-Yi
    Wu, Wei-Hsin
    Chen, Jau-Shiuh
    Liu, I-Lin
    Chiu, Hsueh-Ling
    Chen, Hsi-Wen
    Tsai, Tung-Lin
    Huang, Yi-Ling
    Wang, Li-Fang
    IMMUNOLOGY AND CELL BIOLOGY, 2020, 98 (03): : 215 - 228
  • [42] INDUCTION AND CHARACTERIZATION OF ANERGY IN T-CELLS OF THE TH2 PHENOTYPE
    SLOANLANCASTER, J
    ALLEN, PM
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 449 - 449
  • [43] Activation of Dendritic Cells by IL-33 Initiates a Th2 Response
    Rank, M. A.
    Kabayashi, T.
    Bartemes, K. R.
    Kita, H.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (02) : S53 - S53
  • [44] A role for plasmacytoid dendritic cells in promoting Th2 immunity against helminths
    Lundie, R. J.
    Webb, L. M.
    Cook, P. C.
    Phythian-Adams, A. T.
    Jones, L. H.
    Boon, L.
    MacDonald, A. S.
    IMMUNOLOGY, 2012, 137 : 552 - 552
  • [45] The role of dendritic cells in inducing Th2 responses to schistosoma mansoni eggs
    Mayer, J.
    Webb, L.
    Houston, S.
    Cerovic, V.
    MacDonald, A.
    Milling, S.
    IMMUNOLOGY, 2014, 143 : 40 - 40
  • [46] Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles
    Connor, Lisa M.
    Tang, Shiau-Choot
    Cognard, Emmanuelle
    Ochiai, Sotaro
    Hilligan, Kerry L.
    Old, Samuel I.
    Pellefigues, Christophe
    White, Ruby F.
    Patel, Deepa
    Smith, Adam Alexander T.
    Eccles, David A.
    Lamiable, Olivier
    McConnell, Melanie J.
    Ronchese, Franca
    JOURNAL OF EXPERIMENTAL MEDICINE, 2017, 214 (01): : 125 - 142
  • [47] The dendritic cells that prime Th2 immune responses in vivo are transcriptionally heterogeneous
    Connor, L.
    Cognard, E.
    Ochiai, S.
    Tang, S. C.
    Hilligan, K.
    Old, S.
    Pellefigues, C.
    Smith, A. T.
    Eccles, D.
    McConnell, M.
    Ronchese, F.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 274 - 274
  • [48] The role of dendritic cells in inducing Th2 responses to schistosoma mansoni eggs
    Mayer, J-U
    Webb, L.
    Houston, S.
    Cerovic, V.
    MacDonald, A.
    Milling, S.
    IMMUNOLOGY, 2013, 140 : 107 - 108
  • [49] Modulating Th1/Th2 responses with microbes, dendritic cells, and pathogen recognition receptors
    Bali Pulendran
    Immunologic Research, 2004, 29 : 187 - 196
  • [50] Modulating Th1/Th2 responses with microbes, dendritic cells, and pathogen recognition receptors
    Pulendran, B
    IMMUNOLOGIC RESEARCH, 2004, 29 (1-3) : 187 - 196
12345