Alarming dendritic cells for Th2 induction

被引：125

作者：

MacDonald, Andrew S. ^{[1
]}

Maizels, Rick M. ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Immunol & Infect Res, Ashworth Lab, Edinburgh EH9 3JT, Midlothian, Scotland

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1084/jem.20072665

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.

引用

页码：13 / 17

页数：5

共 50 条

[31] Induction of primate TH2 lymphokines to suppress TH1 cells
Smit, JA
Stark, JH
Myburgh, JA
TRANSPLANTATION PROCEEDINGS, 1996, 28 (02) : 665 - 666
[32] A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells
Peter C. Cook
Heather Owen
Aimée M. Deaton
Jessica G. Borger
Sheila L. Brown
Thomas Clouaire
Gareth-Rhys Jones
Lucy H. Jones
Rachel J. Lundie
Angela K. Marley
Vicky L. Morrison
Alexander T. Phythian-Adams
Elisabeth Wachter
Lauren M. Webb
Tara E. Sutherland
Graham D. Thomas
John R. Grainger
Jim Selfridge
Andrew N. J. McKenzie
Judith E. Allen
Susanna C. Fagerholm
Rick M. Maizels
Alasdair C. Ivens
Adrian Bird
Andrew S. MacDonald
Nature Communications, 6
[33] Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells
Kazunori Onoé
Yoshiki Yanagawa
Keita Minami
Norifumi Iijima
Kazuya Iwabuchi
Immunologic Research, 2007, 38 : 319 - 332
[34] Epigenetic control of Th2 induction by dendritic cells via the methyl-CpG binding protein Mbd2
Cook, P.
Owen, H.
Deaton, A.
Borger, J.
Clouaire, T.
Jones, G. -R.
Jones, L.
Lundie, R.
Marley, A.
Morrison, V.
Phythian-Adams, A.
IMMUNOLOGY, 2013, 140 : 84 - 84
[35] Th1or Th2 balance regulated by interaction between dendritic cells and NKT cells
Ono, Kazunori
Yanagawa, Yoshiki
Minami, Keita
Iijima, Norifurni
Iwabuchi, Kazuya
IMMUNOLOGIC RESEARCH, 2007, 38 (1-3) : 319 - 332
[36] A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells
Cook, Peter C.
Owen, Heather
Deaton, Aimee M.
Borger, Jessica G.
Brown, Sheila L.
Clouaire, Thomas
Jones, Gareth-Rhys
Jones, Lucy H.
Lundie, Rachel J.
Marley, Angela K.
Morrison, Vicky L.
Phythian-Adams, Alexander T.
Wachter, Elisabeth
Webb, Lauren M.
Sutherland, Tara E.
Thomas, Graham D.
Grainger, John R.
Selfridge, Jim
McKenzie, Andrew N. J.
Allen, Judith E.
Fagerholm, Susanna C.
Maizels, Rick M.
Ivens, Alasdair C.
Bird, Adrian
MacDonald, Andrew S.
NATURE COMMUNICATIONS, 2015, 6
[37] Investigating dendritic cell subsets during Th2 induction against helminth infection
Marley, A.
Phythian-Adams, A.
Cook, P.
Jones, G. -R.
Jones, L.
Webb, L.
Maizels, R.
MacDonald, A.
IMMUNOLOGY, 2013, 140 : 201 - 201
[38] Myeloid dendritic cells are primed in allergic asthma for thymic stromal lymphopoietin-mediated induction of Th2 and Th9 responses
Froidure, A.
Shen, C.
Gras, D.
Van Snick, J.
Chanez, P.
Pilette, C.
ALLERGY, 2014, 69 (08) : 1068 - 1076
[39] Dendritic cells control the differentiation of Th1 and Th2 lymphocytic subsets in human
Soumelis, V
Rissoan, MC
Kadowaki, N
Liu, YJ
M S-MEDECINE SCIENCES, 1999, 15 (8-9): : 1025 - 1026
[40] Th1/Th2 xenogenic antibody responses are associated with recipient dendritic cells
Kanai, Nobuyuki
Min, Wei-Ping
Ichim, Thomas E.
Wang, Hao
Zhong, Robert
MICROSURGERY, 2007, 27 (04) : 234 - 239

← 1 2 3 4 5 →