Alarming dendritic cells for Th2 induction

被引：125
|
作者：
MacDonald, Andrew S. [1 ]
Maizels, Rick M. [1 ]
机构：
[1] Univ Edinburgh, Inst Immunol & Infect Res, Ashworth Lab, Edinburgh EH9 3JT, Midlothian, Scotland
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 01期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
D O I：
10.1084/jem.20072665
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses. This gap in our knowledge puts us at a distinct disadvantage in designing therapeutics for certain immune-mediated diseases. However, progress is being made with the identification of novel endogenous tissue factors that can enhance Th2 induction by DCs.
引用
收藏
页码：13 / 17
页数：5
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