Rh(iii)-Catalyzed regioselective C4 alkylation of indoles with allylic alcohols: direct access to β-indolyl ketones

被引：20
|
作者：
Pan, Changduo [1 ]
Huang, Gao [2 ]
Shan, Yujia [2 ]
Li, Yiting [2 ]
Yu, Jin-Tao [2 ]
机构：
[1] Jiangsu Univ Technol, Sch Chem & Environm Engn, Changzhou 213001, Peoples R China
[2] Changzhou Univ, Jiangsu Key Lab Adv Catalyt Mat & Technol, Sch Petrochem Engn, Changzhou 213164, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 16期
基金：
中国国家自然科学基金;
关键词：
H ACTIVATION; OXIDATIVE ALKYLATION; HECK REACTION; FUNCTIONALIZATION; ALLYLATION; ARYLATION; OLEFINATION; C7-FUNCTIONALIZATION; ALKENYLATION; INDOLINES;
D O I：
10.1039/d0ob00396d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Rh(iii)-catalyzed and weak coordination carbonyl guided direct C4 alkylation of indoles with allylic alcohols was developed with excellent regioselectivity. This reaction was conducted under mild conditions, leading to a variety of beta-indolyl ketones with good functional group tolerance in moderate to good yields.
引用
收藏
页码：3038 / 3042
页数：5
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