Palladium-Catalyzed Direct 2-Alkylation of Indoles by Norbornene-Mediated Regioselective Cascade C-H Activation

被引：285

作者：

Jiao, Lei

Bach, Thorsten ^{[1
]}

机构：

[1] Tech Univ Munich, Lehrstuhl Organ Chem 1, D-85747 Garching, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 33期

关键词：

ELECTRON-WITHDRAWING SUBSTITUENTS; DIRECT ARYLATION; PROTECTING GROUP; FUNCTIONALIZATION; ALKENYLATION; PYRROLES; OLEFINS; ROUTE; ALKYL; SELECTIVITY;

D O I：

10.1021/ja2055066

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed direct 2-alkylation reaction of free N-H indoles has been developed. This reaction relies on a norbornene-mediated cascade C-H activation process at the indole ring, which features high regioselectivity and excellent functional group, tolerance. The reaction represents the first example for a generally applicable, direct C-H alkylation of indole at the 2-position.

引用

页码：12990 / 12993

页数：4

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