Palladium-catalyzed direct C2-arylation of free (N-H) indoles via norbornene-mediated regioselective C-H activation

被引：27
|
作者：
Gao, Yadong [1 ]
Zhu, Wangying [1 ]
Yin, Long [1 ]
Dong, Bo [1 ]
Fu, Jingjing [1 ]
Ye, Zhiwen [1 ]
Xue, Fengtian [2 ]
Jiang, Chao [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Dept Pharmaceut Engn, Nanjing 210094, Jiangsu, Peoples R China
[2] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, 20 Penn St, Baltimore, MD 21201 USA
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 23期
基金：
中国国家自然科学基金;
关键词：
Palladium; Norbornene; Free (N-H) indoles; Arylation; DIRECT C-2 ARYLATION; ARYL BORONIC ACIDS; BOND ARYLATION; ROOM-TEMPERATURE; SELECTIVE ARYLATION; FREE (NH)-INDOLES; FUNCTIONALIZATION; EFFICIENT; SALTS; DERIVATIVES;
D O I：
10.1016/j.tetlet.2017.04.066
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed direct C2-arylation reaction of free (N-H) indoles has been developed. This reaction relies on a norbornene-mediated C-H activation process on the indole ring, which features high regioselectivity and excellent functional group tolerance. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2213 / 2216
页数：4
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