Metal-Free Aerobic Oxidative Cyanation of Tertiary Amines: Azobis(isobutyronitrile) (AIBN) as a Sole Cyanide Source

被引：27
|
作者：
Liu, Peng-Yu [1 ]
Zhang, Chao [1 ]
Zhao, Shi-Chen [1 ]
Yu, Fang [1 ]
Li, Fei [1 ]
He, Yu-Peng [1 ]
机构：
[1] Liaoning Shihua Univ, Coll Chem Chem Engn & Environm Engn, Dandong Lu West 1, Fushun 113001, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 23期
基金：
中国国家自然科学基金;
关键词：
COPPER-CATALYZED CYANATION; H BOND ACTIVATION; ALPHA-CYANATION; STRECKER REACTION; SODIUM-CYANIDE; COUPLING REACTIONS; HYDROGEN-PEROXIDE; HIGHLY EFFICIENT; NITRILES; AZOBISISOBUTYRONITRILE;
D O I：
10.1021/acs.joc.7b02021
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An aerobic oxidative cyanation for the synthesis of alpha-aminonitriles was reported. The formation of C(sp(3))-CN bonds was achieved under a metal-free condition by utilizing azobis(isobutyronitrile) as a sole organic cyanide source with the combination of pivalic acid and sodium acetate as additives.
引用
收藏
页码：12786 / 12790
页数：5
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