Flexible two-stage designs: An overview

被引：0
|
作者：
Bauer, P [1 ]
Brannath, W [1 ]
Posch, M [1 ]
机构：
[1] Univ Vienna, Dept Med Stat, A-1090 Vienna, Austria
来源：
METHODS OF INFORMATION IN MEDICINE | 2001年 / 40卷 / 02期
关键词：
adaptive design; midtrial design modification; two-stage combination test; conditional error function; confidence interval; recursive combination test;
D O I：
暂无
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
In this overview we introduce the basic ideas behind a new flexible approach in sequential designs. The different concepts based on two-stage combination tests and conditional error functions are brought together. We sketch the construction of p-values, confidence intervals, and median unbiased estimates. Finally, recursive combination tests are introduced which extend the flexibility to the choice of the number of interim analyses.
引用
收藏
页码：117 / 121
页数：5
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