Flexible two-stage designs: An overview

被引：0

作者：

Bauer, P ^{[1
]}

Brannath, W ^{[1
]}

Posch, M ^{[1
]}

机构：

[1] Univ Vienna, Dept Med Stat, A-1090 Vienna, Austria

来源：

METHODS OF INFORMATION IN MEDICINE | 2001年 / 40卷 / 02期

关键词：

adaptive design; midtrial design modification; two-stage combination test; conditional error function; confidence interval; recursive combination test;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

In this overview we introduce the basic ideas behind a new flexible approach in sequential designs. The different concepts based on two-stage combination tests and conditional error functions are brought together. We sketch the construction of p-values, confidence intervals, and median unbiased estimates. Finally, recursive combination tests are introduced which extend the flexibility to the choice of the number of interim analyses.

引用

页码：117 / 121

页数：5

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